rs7753394
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.5x risk of Crohn's disease | |
| (C;T) | 1.2x risk of Crohn's disease | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 137764111 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7753394 |
| dbSNP (classic) | rs7753394 |
| ClinGen | rs7753394 |
| ebi | rs7753394 |
| HLI | rs7753394 |
| Exac | rs7753394 |
| Gnomad | rs7753394 |
| Varsome | rs7753394 |
| LitVar | rs7753394 |
| Map | rs7753394 |
| PheGenI | rs7753394 |
| Biobank | rs7753394 |
| 1000 genomes | rs7753394 |
| hgdp | rs7753394 |
| ensembl | rs7753394 |
| geneview | rs7753394 |
| scholar | rs7753394 |
| rs7753394 | |
| pharmgkb | rs7753394 |
| gwascentral | rs7753394 |
| openSNP | rs7753394 |
| 23andMe | rs7753394 |
| SNPshot | rs7753394 |
| SNPdbe | rs7753394 |
| MSV3d | rs7753394 |
| GWAS Ctlg | rs7753394 |
| GMAF | 0.4343 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs7753394 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.21 (CI 1.04-1.40), and for homozygotes, 1.48 (CI 1.25-1.76). [PMID 17554300
]
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 19956648] Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.
