rs7837688
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | Normal |
| (G;T) | 2.1 | 1.7x increased risk for prostate cancer |
| (T;T) | 2.1 | 1.7x increased risk for prostate cancer |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 127527115 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7837688 |
| dbSNP (classic) | rs7837688 |
| ClinGen | rs7837688 |
| ebi | rs7837688 |
| HLI | rs7837688 |
| Exac | rs7837688 |
| Gnomad | rs7837688 |
| Varsome | rs7837688 |
| LitVar | rs7837688 |
| Map | rs7837688 |
| PheGenI | rs7837688 |
| Biobank | rs7837688 |
| 1000 genomes | rs7837688 |
| hgdp | rs7837688 |
| ensembl | rs7837688 |
| geneview | rs7837688 |
| scholar | rs7837688 |
| rs7837688 | |
| pharmgkb | rs7837688 |
| gwascentral | rs7837688 |
| openSNP | rs7837688 |
| 23andMe | rs7837688 |
| SNPshot | rs7837688 |
| SNPdbe | rs7837688 |
| MSV3d | rs7837688 |
| GWAS Ctlg | rs7837688 |
| GMAF | 0.1097 |
| Max Magnitude | 2.1 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs7837688 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295.[PMID 17925536]
In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.[PMID 17925536]
| GWAS snp | |
|---|---|
| PMID | [PMID 20676098] |
| Trait | |
| Title | Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population |
| Risk Allele | |
| P-val | 1E-25 |
| Odds Ratio | None None |
[PMID 18231127
] 8q24 and prostate cancer: association with advanced disease and meta-analysis.
[PMID 18535017] Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
[PMID 18704501] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
[PMID 19528667] Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21455501] Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature.
[PMID 22382457] Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.
[PMID 23532531] Common Variants at 8q24 are Associated with Prostate Cancer Risk in Serbian Population
