rs7865618
| Orientation | plus |
| Stabilized | plus |
| Make rs7865618(A;A) |
| Make rs7865618(A;G) |
| Make rs7865618(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 9 |
| Position | 22031006 |
| Gene | CDKN2B-AS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7865618 |
| dbSNP (classic) | rs7865618 |
| ClinGen | rs7865618 |
| ebi | rs7865618 |
| HLI | rs7865618 |
| Exac | rs7865618 |
| Gnomad | rs7865618 |
| Varsome | rs7865618 |
| LitVar | rs7865618 |
| Map | rs7865618 |
| PheGenI | rs7865618 |
| Biobank | rs7865618 |
| 1000 genomes | rs7865618 |
| hgdp | rs7865618 |
| ensembl | rs7865618 |
| geneview | rs7865618 |
| scholar | rs7865618 |
| rs7865618 | |
| pharmgkb | rs7865618 |
| gwascentral | rs7865618 |
| openSNP | rs7865618 |
| 23andMe | rs7865618 |
| SNPshot | rs7865618 |
| SNPdbe | rs7865618 |
| MSV3d | rs7865618 |
| GWAS Ctlg | rs7865618 |
| GMAF | 0.2094 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| Rs7865618 | |
|---|---|
| PubMed | [PMID 17634449 ]
|
| Affy Probeset | SNP_A-1948244 |
| Affy Orientation | same |
| On GW 5.0 | 1 |
| Alleles A/B | A/G |
| Ancestral | A |
| Population | Caucasian |
| Allele | A |
| Case Freq. | 0.61 |
| Control Freq. | 0.55 |
| Odds Ratio Het | 1.23 |
| Odds Ratio Hom | 1.57 |
| Odds Ratio All | 1.26 |
| Disease | Coronary artery disease (CAD) |
rs7865618 increases susceptibility to Coronary artery disease 1.23 times for heterozygotes (AG) and 1.57 times for homozygotes (AA) [PMID 17634449]
[PMID 18675980] Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
[PMID 19926059] No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents
[PMID 21511257] The chromosome 9p21 region and myocardial infarction in a European population
| GWAS snp | |
|---|---|
| PMID | [PMID 21606135]
|
| Trait | |
| Title | A Genome-wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease. |
| Risk Allele | A |
| P-val | 2E-27 |
| Odds Ratio | 1.1800 [1.14-1.21] |
| GWAS snp | |
|---|---|
| PMID | [PMID 22428042]
|
| Trait | |
| Title | Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese. |
| Risk Allele | A |
| P-val | 9E-11 |
| Odds Ratio | 1.7800 None |
[PMID 18362232] Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
[PMID 19214202] Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.
[PMID 19475673] Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke.
[PMID 20386740] Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
[PMID 20696043] Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort.
[PMID 24820060] Association between Polymorphisms rs1333040 and rs7865618 of Chromosome 9p21 and Sporadic Brain Arteriovenous Malformations
[PMID 29773352] The ANRIL Genetic Variants and Their Interactions with Environmental Risk Factors on Atherothrombotic Stroke in a Han Chinese Population.
[PMID 31543200] Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population.
[PMID 32933932] Genetic analysis of primary open-angle glaucoma-related risk alleles in a Korean population: the GLAU-GENDISK study.
[PMID 33298998] The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population.
