rs8040868
| Orientation | plus |
| Stabilized | plus |
| Make rs8040868(C;C) |
| Make rs8040868(C;T) |
| Make rs8040868(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 15 |
| Position | 78618839 |
| Gene | CHRNA3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs8040868 |
| dbSNP (classic) | rs8040868 |
| ClinGen | rs8040868 |
| ebi | rs8040868 |
| HLI | rs8040868 |
| Exac | rs8040868 |
| Gnomad | rs8040868 |
| Varsome | rs8040868 |
| LitVar | rs8040868 |
| Map | rs8040868 |
| PheGenI | rs8040868 |
| Biobank | rs8040868 |
| 1000 genomes | rs8040868 |
| hgdp | rs8040868 |
| ensembl | rs8040868 |
| geneview | rs8040868 |
| scholar | rs8040868 |
| rs8040868 | |
| pharmgkb | rs8040868 |
| gwascentral | rs8040868 |
| openSNP | rs8040868 |
| 23andMe | rs8040868 |
| SNPshot | rs8040868 |
| SNPdbe | rs8040868 |
| MSV3d | rs8040868 |
| GWAS Ctlg | rs8040868 |
| GMAF | 0.3774 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19859904
] Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans
[PMID 22280835] New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer
[PMID 18163978] The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.
[PMID 18165968] Identification of pharmacogenetic markers in smoking cessation therapy.
[PMID 19330903] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 20808433] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
[PMID 22042234] Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.
[PMID 23196875] Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder
| GWAS snp | |
|---|---|
| PMID | [PMID 23284291]
|
| Trait | Pulmonary function (interaction) |
| Title | Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. |
| Risk Allele | T |
| P-val | 9E-8 |
| Odds Ratio | NR NR |
[PMID 22945651] Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4.
| GWAS snp | |
|---|---|
| PMID | [PMID 23251661]
|
| Trait | Obesity-related traits |
| Title | Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. |
| Risk Allele | G |
| P-val | 6E-8 |
| Odds Ratio | .05 [NR] kcal/d increase |
[PMID 25399010] Association between polymorphisms in CHRNA3 and PHACTR2 gene and environment and NSCLC risk in Chinese population
