rs8177374
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | very common, but it seems better to have the minor allele which is protective against several diseases |
| (C;T) | 3 | resistance to several diseases |
| (T;T) | 3.5 | resistance to several diseases |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 126292948 |
| Gene | TIRAP |
| is a | snp |
| is | mentioned by |
| dbSNP | rs8177374 |
| dbSNP (classic) | rs8177374 |
| ClinGen | rs8177374 |
| ebi | rs8177374 |
| HLI | rs8177374 |
| Exac | rs8177374 |
| Gnomad | rs8177374 |
| Varsome | rs8177374 |
| LitVar | rs8177374 |
| Map | rs8177374 |
| PheGenI | rs8177374 |
| Biobank | rs8177374 |
| 1000 genomes | rs8177374 |
| hgdp | rs8177374 |
| ensembl | rs8177374 |
| geneview | rs8177374 |
| scholar | rs8177374 |
| rs8177374 | |
| pharmgkb | rs8177374 |
| gwascentral | rs8177374 |
| openSNP | rs8177374 |
| 23andMe | rs8177374 |
| SNPshot | rs8177374 |
| SNPdbe | rs8177374 |
| MSV3d | rs8177374 |
| GWAS Ctlg | rs8177374 |
| GMAF | 0.08402 |
| Max Magnitude | 3.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
23andMe blog rs8177374(T) less susceptible to infection with malaria, tuberculosis, bacteremia and pneumococcal disease.
[PMID 19509334
] Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
| ClinVar | |
|---|---|
| Risk | Rs8177374(T;T) |
| Alt | Rs8177374(T;T) |
| Reference | Rs8177374(C;C) |
| Significance | Other |
| Disease | Invasive pneumococcal disease Malaria Mycobacterium tuberculosis Bacteremia |
| Variation | info |
| Gene | TIRAP |
| CLNDBN | Invasive pneumococcal disease, protection against Malaria, resistance to Mycobacterium tuberculosis, protection against Bacteremia, resistance to |
| Reversed | 0 |
| HGVS | NC_000011.9:g.126162843C>T |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000004722.2, RCV000004723.2, RCV000004724.2, RCV000023527.2, |
[PMID 19543401] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
[PMID 20016852] Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
[PMID 20525286] Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
[PMID 21274447] Genetic polymorphisms and posttraumatic complications.
[PMID 21399862] Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.
[PMID 23047423] A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth
[PMID 22691414] Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children
[PMID 24064014] TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts
[PMID 23255565] Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.
[PMID 24067789] The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis
