| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
normal
|
| (A;G)
|
|
1.58x increased risk of Alzheimer's
|
| (G;G)
|
|
1.48x increased risk of Alzheimer's
|
| Rs911541
|
| PubMed
|
[PMID 16740596]
|
| Affy Probeset
|
SNP_A-2173989
|
| Affy Orientation
|
same
|
| On GW 5.0
|
0
|
| Alleles A/B
|
A/G
|
| Ancestral
|
G
|
| Population
|
Japanese
|
| Allele
|
G
|
| Case Freq.
|
0.22
|
| Control Freq.
|
0.17
|
| Odds Ratio Het
|
1.58
|
| Odds Ratio Hom
|
1.48
|
| Odds Ratio All
|
1.43
|
| Disease
|
Alzheimer's disease, late-onset (LOAD)
|
rs911541 increases susceptibility to late-onset Alzheimer's disease 1.58 times for heterozygotes (A;G) and 1.48 times for homozygotes (G;G,) based on a case-control study of ~1,500 Japanese patients and an equal number of matched controls. [PMID 16740596]
