rs9273363

23andMe's Type 1 Diabetes SNP

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	2	Higher risk of Type 1 Diabetes.
(A;C)	2	Lower 0.87x risk of Type 1 Diabetes.
(C;C)	2.1	Much lower 0.15x risk of Type 1 Diabetes.

Reference

GRCh38 38.1/141

Chromosome

6

Position

32658495

Gene	HLA-DQB1-AS1

is a	snp
is	mentioned by
dbSNP	rs9273363
dbSNP (classic)	rs9273363
ClinGen	rs9273363
ebi	rs9273363
HLI	rs9273363
Exac	rs9273363
Gnomad	rs9273363
Varsome	rs9273363
LitVar	rs9273363
Map	rs9273363
PheGenI	rs9273363
Biobank	rs9273363
1000 genomes	rs9273363
hgdp	rs9273363
ensembl	rs9273363
geneview	rs9273363
scholar	rs9273363
google	rs9273363
pharmgkb	rs9273363
gwascentral	rs9273363
openSNP	rs9273363
23andMe	rs9273363
SNPshot	rs9273363
SNPdbe	rs9273363
MSV3d	rs9273363
GWAS Ctlg	rs9273363

GMAF

0.2576

Max Magnitude

2.1

?	(A;A) (A;C) (C;C)	28

This is one of the SNPs that 23andMe uses for Type 1 diabetes. According to 23andMe, this SNP changes your risk of Type 1 Diabetes. That is an autoimmune disease where your immune system attacks your own body's insulin producing cells in the pancreas, preventing your blood sugar from being able to enter cells that need energy. This has been verified for white people. 23andMe originally wanted to use rs9272346 instead, but it was deemed unreliable.

GWAS snp
PMID	[PMID 23770605]
Trait	Chronic lymphocytic leukemia
Title	Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Risk Allele	A
P-val	2E-10
Odds Ratio	1.24 [NR]

[PMID 19956648] Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

[PMID 20018019] Two-stage joint selection method to identify candidate markers from genome-wide association studies.