rs9303277

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	1	Normal risk of developing primary biliary cirrhosis
(C;T)	1.5	1.46x Slightly increased risk of developing primary biliary cirrhosis
(T;T)	2	1.46x Increased risk of developing primary biliary cirrhosis

Reference

GRCh38 38.1/141

Chromosome

17

Position

39820216

Gene

IKZF3

is a	snp
is	mentioned by
dbSNP	rs9303277
dbSNP (classic)	rs9303277
ClinGen	rs9303277
ebi	rs9303277
HLI	rs9303277
Exac	rs9303277
Gnomad	rs9303277
Varsome	rs9303277
LitVar	rs9303277
Map	rs9303277
PheGenI	rs9303277
Biobank	rs9303277
1000 genomes	rs9303277
hgdp	rs9303277
ensembl	rs9303277
geneview	rs9303277
scholar	rs9303277
google	rs9303277
pharmgkb	rs9303277
gwascentral	rs9303277
openSNP	rs9303277
23andMe	rs9303277
SNPshot	rs9303277
SNPdbe	rs9303277
MSV3d	rs9303277
GWAS Ctlg	rs9303277

GMAF

0.4858

Max Magnitude

2

?	(C;C) (C;T) (T;T)	28

GWAS snp
PMID	[PMID 20639880]
Trait	Primary biliary cirrhosis
Title	Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Risk Allele	T
P-val	2E-9
Odds Ratio	1.38 [NR]

OMIM	611403
Desc
Variant
Related	also

[PMID 21985515] Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population

[PMID 19426955] Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

[PMID 19458352] Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

[PMID 19714205] Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

[PMID 19732864] Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

[PMID 20698975] Asthma-susceptibility variants identified using probands in case-control and family-based analyses.

GWAS snp
PMID	[PMID 23000144]
Trait	Primary biliary cirrhosis
Title	Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
Risk Allele	T
P-val	4E-9
Odds Ratio	1.44 [1.28-1.63]

[PMID 23154084] Examination of the relationship between variation at 17q21 and childhood wheeze phenotypes

[PMID 23157251] Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population

GWAS snp
PMID	[PMID 23740937]
Trait	Systemic lupus erythematosus and Systemic sclerosis
Title	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
Risk Allele
P-val	7E-6
Odds Ratio	1.19 [NR]