Geno
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Mag
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Summary
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(C;C)
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<0.63x risk for restless legs
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(C;T)
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0.63x risk for restless legs
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(T;T)
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1
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Normal risk of developing restless legs syndrome
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rs9357271, a SNP located in the BTBD9 gene region, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.63 (CI: 0.52-0.75) for the (C) minor allele. [PMID 17637780]
This SNP may also be associated with Tourette syndrome (TS), particularly TS without obsessive-compulsive disorder, based on a study of ~600 patients.[PMID 19822783]
OMIM | 611185 |
Desc | RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 6 |
Variant | |
Related | also |
GWAS snp
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PMID
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[PMID 21779176]
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Trait
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Title
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Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
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Risk Allele
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T
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P-val
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8E-22
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Odds Ratio
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1.4700 [1.35-1.47]
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[PMID 23361623] The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia
[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
[PMID 26597663] Genetic factors influencing ferritin levels in 14,126 blood donors: results from the Danish Blood Donor Study
[PMID 28329290] Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome in Chinese Population.