rs951266
| Orientation | minus |
| Stabilized | minus |
| Make rs951266(C;C) |
| Make rs951266(C;T) |
| Make rs951266(T;T) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 15 |
| Position | 78586199 |
| Gene | CHRNA5 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs951266 |
| dbSNP (classic) | rs951266 |
| ClinGen | rs951266 |
| ebi | rs951266 |
| HLI | rs951266 |
| Exac | rs951266 |
| Gnomad | rs951266 |
| Varsome | rs951266 |
| LitVar | rs951266 |
| Map | rs951266 |
| PheGenI | rs951266 |
| Biobank | rs951266 |
| 1000 genomes | rs951266 |
| hgdp | rs951266 |
| ensembl | rs951266 |
| geneview | rs951266 |
| scholar | rs951266 |
| rs951266 | |
| pharmgkb | rs951266 |
| gwascentral | rs951266 |
| openSNP | rs951266 |
| 23andMe | rs951266 |
| SNPshot | rs951266 |
| SNPdbe | rs951266 |
| MSV3d | rs951266 |
| GWAS Ctlg | rs951266 |
| GMAF | 0.1892 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| Rs951266 | |
|---|---|
| PubMed | [PMID 18385738] |
| Affy Probeset | SNP_A-4302972 |
| Affy Orientation | same |
| On GW 5.0 | |
| Alleles A/B | C/T |
| Ancestral | C |
| Population | Caucasian(Europe) |
| Allele | T |
| Case Freq. | 0.4 |
| Control Freq. | 0.34 |
| Odds Ratio Het | |
| Odds Ratio Hom | |
| Odds Ratio All | 1.30 |
| Disease | Lung cancer (LC) |
rs951266 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.80 times for homozygotes (TT) [PMID 18385676
]
rs951266 increases susceptibility to Lung cancer 1.30 times for carriers of the T allele [PMID 18385738]
rs951266 increases susceptibility to Lung cancer 1.32 times for heterozygotes (CT) and 1.70 times for homozygotes (TT) [PMID 18385739]
rs951266 increases susceptibility to Peripheral arterial disease 1.21 times for heterozygotes (CT) and 1.41 times for homozygotes (TT) [PMID 18385739]
rs951266 increases susceptibility to Substance dependence, Nicotine 1.10 times for heterozygotes (CT) and 1.90 times for homozygotes (TT) [PMID 17135278]
rs951266 increases susceptibility to Substance dependence, Nicotine 1.39 times for heterozygotes (CT) and 1.97 times for homozygotes (TT) [PMID 18385739]
plos Risk Factors for Age-Dependent Nicotine Addiction
[PMID 17373692] No evidence for association between 19 cholinergic genes and bipolar disorder.
[PMID 18227835] Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking.
[PMID 18618000] A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
[PMID 18759969] In search of causal variants: refining disease association signals using cross-population contrasts.
[PMID 19330903] Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans.
[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
[PMID 20808433] Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
[PMID 23196875] Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder
