rs966221
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 1.5 | 1.5x increased stroke risk certain populations |
| (C;T) | 1.5x increased stroke risk | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 60206693 |
| Gene | PDE4D |
| is a | snp |
| is | mentioned by |
| dbSNP | rs966221 |
| dbSNP (classic) | rs966221 |
| ClinGen | rs966221 |
| ebi | rs966221 |
| HLI | rs966221 |
| Exac | rs966221 |
| Gnomad | rs966221 |
| Varsome | rs966221 |
| LitVar | rs966221 |
| Map | rs966221 |
| PheGenI | rs966221 |
| Biobank | rs966221 |
| 1000 genomes | rs966221 |
| hgdp | rs966221 |
| ensembl | rs966221 |
| geneview | rs966221 |
| scholar | rs966221 |
| rs966221 | |
| pharmgkb | rs966221 |
| gwascentral | rs966221 |
| openSNP | rs966221 |
| 23andMe | rs966221 |
| SNPshot | rs966221 |
| SNPdbe | rs966221 |
| MSV3d | rs966221 |
| GWAS Ctlg | rs966221 |
| GMAF | 0.4922 |
| Max Magnitude | 1.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18694398] A study of 639 Chinese stroke patients concluded that the rs966221(C) allele is associated with increased risk for atherothrombotic strokes (odds ratio 1.51, CI: 1.09-2.10) in this population.
[PMID 21677445] Meta-Analysis of Homogeneous Subgroups Reveals Association between PDE4D Gene Variants and Ischemic Stroke
[PMID 16130105
] Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
[PMID 16166573] Association of phosphodiesterase 4D gene with ischemic stroke in a Pakistani population.
[PMID 16835261] Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study.
[PMID 19409523] Multilocus Bayesian meta-analysis of gene-disease associations.
[PMID 20031584] Genetics of atherothrombotic and lacunar stroke.
[PMID 20540798] Sex-differential genetic effect of phosphodiesterase 4D (PDE4D) on carotid atherosclerosis.
[PMID 23786009] [Association of rs966221 phosphodiesterase 4D gene's polymorphism with risk of myocardial infarction]
[PMID 23774910] [Association study between PDE4D gene polymorphism and ischemic stroke].
[PMID 28191858] Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population.
