Trimethylaminuria
At a minimum, these SNPs are known to be related, and others may also be
Max Magnitude | |
---|---|
rs1736557 | 1.1 |
rs2266780 | 0 |
rs2266782 | 0 |
rs28363581 | 0 |
rs3832024 | 0 |
rs61753344 | 3 |
rs72549320 | 2 |
rs72549321 | 2 |
rs72549322 | 2 |
rs72549323 | 2 |
rs72549326 | 2 |
rs72549330 | 2 |
rs72549331 | 2 |
rs72549332 | 2 |
rs72549334 | 2 |
rs769983049 | 0 |
rs909530 | 0 |
Trimethylaminuria (TMAU), also known as fish odor syndrome, is a rare metabolic disorder resulting from too little of the enzyme known as flavin containing monooxygenase 3 (FMO3). When this enzyme is not working correctly or if not enough enzyme is produced, the body loses the ability to properly convert trimethylamine (TMA) from tyramine-containing foods (such as cheese) into trimethylamine oxide (TMAO). Trimethylamine then builds up and is released in the person's sweat, urine, and breath, giving off a strong fishy odor or strong body odor.Wikipedia
Note that cases of trimethylaminuria have been reported from carriers of a single defective FMO3 allele, as well as from homozygous minor allele genotypes.