Venous thromboembolism
From SNPedia
(Redirected from Venous thromboembolism (gene x gene interaction))
Venous thromboembolism or VTE is a term used to describe deep vein thrombosis, with or without the complication of pulmonary embolism. As mentioned in this Wikipedia article, VTE is also known as economy class syndrome.
SNPs in several genes can raise the risk of developing venous thromboembolism:
- rs6025, the Leiden R506Q mutation of the Factor V F5 gene
- rs1799963, the 20210G>A SNP of the prothrombin F2 gene
- rs201381904, the V295M mutation in the SERPINC1 gene
- rs5361, in the SELE gene
- rs268, in the lipoprotein lipase LPL gene
- rs1042714, in the ADRB2 gene
- rs657152 [PMID 19278955]
- rs2288904, in the SLC44A2 gene
- rs78707713, in the TSPAN15 gene
- rs138925964, in the PROS1 gene
Several other SNPs have lesser effects:
- rs9574, tagging the EPCR H1 haplotype
- rs867186, tagging the EPCR H3 haplotype
- rs1613662 in the GP6 gene [PMID 19278955]
- rs13146272 in the CYP4V2 gene [PMID 19278955]
The CYP3A5*1 allele appears to be significantly associated with higher risk for venous thromboembolism among postmenopausal women taking oral estrogen. [PMID 18628519]
