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| | [http://www.23andme.com 23andMe] is a private biotech company based in the USA. | | [http://www.23andme.com 23andMe] is a private biotech company based in the USA. |
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| − | The Ancestry only product produces the same [[Promethease]] report as the Ancestry + Health product | + | 23andMe users are encouraged to use [[Promethease]] to produce a report based on their raw data; data from all chip versions is suitable. The Ancestry-only product from 23andMe produces exactly the same [[Promethease]] report as their Ancestry + Health product. |
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| | You can [https://you.23andme.com/tools/data/download/ download your raw data], but these steps may be helpful if you're on an | | You can [https://you.23andme.com/tools/data/download/ download your raw data], but these steps may be helpful if you're on an |
| | [https://www.snpedia.com/index.php/23andMe/ipad_upload ipad or iphone]. | | [https://www.snpedia.com/index.php/23andMe/ipad_upload ipad or iphone]. |
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| − | There is also a [https://api.23andme.com/ developer API].
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| | + | 23andMe began offering direct-to-consumer genetic [[testing]] in 2007. The chip versions used since then, and the current approximate Promethease report sizes (total number of genotypes out of the 110,000+ in SNPedia) based on them, are as follows: |
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| − | In 2007, they began offering direct-to-consumer genetic [[testing]]. For version 1 and version 2 of their service they used a customized Illumina [http://www.illumina.com/pages.ilmn?ID=157 Hap550+] array. As of November 24, 2010, their version 3 service is based on a customized Illumina [http://www.illumina.com/products/human_omni_express.ilmn OmniExpress+] array.
| + | {| class="wikitable sortable" border="1" |
| − | | + | |- |
| − | August 2017 they introduced a new v5 array, based on the illumina GSA chip. There appears to have been an issue where during the the first 24 hours, many users raw data included only 200k snp, instead of the expected 600k. After that was corrected promethease is seeing way too many warnings of heterozygosity for serious pathogenic BRCA2 snps. see https://www.reddit.com/r/promethease/comments/6stg3t/scary_false_23andme_brca2_miscalls_on_new_v5_chip/ and
| + | ! scope="col" | Chip |
| − | https://www.23andmeforums.com/discussion/comment/89971/
| + | ! scope="col" | Base (Illumina) |
| | + | ! scope="col" | Released |
| | + | ! scope="col" | Report size |
| | + | |- |
| | + | | 1 |
| | + | | Hap550+ |
| | + | | 2007 |
| | + | | 13K |
| | + | |- |
| | + | | 2 |
| | + | | Hap550+ |
| | + | | Oct 2008 |
| | + | | 24K |
| | + | |- |
| | + | | 3 |
| | + | | OmniExpress+ |
| | + | | Nov 2010 |
| | + | | 26K |
| | + | |- |
| | + | | 4 |
| | + | | OmniExpress+ |
| | + | | Nov 2013 |
| | + | | 22K |
| | + | |- |
| | + | | 5 |
| | + | | GSA |
| | + | | Aug 2017 |
| | + | | 24K |
| | + | |- |
| | + | |} |
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| | + | There was also a [https://api.23andme.com/ developer API], but access to it was restricted (eliminated?) in 2018. |
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| | A comparison of the platform's result for [[User:Lilly Mendel]] | | A comparison of the platform's result for [[User:Lilly Mendel]] |
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| | *[http://files.snpedia.com/reports/promethease_data/genome_Lilly_Mendel_v4_ui2.html 23andMe v4] (2014) | | *[http://files.snpedia.com/reports/promethease_data/genome_Lilly_Mendel_v4_ui2.html 23andMe v4] (2014) |
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| − | 23andMe customers may be interested in using [[Promethease]] to learn more about their raw dna.
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| | |?Summary | | |?Summary |
| | }} | | }} |
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| − | Here is a list of [[:Category:On_chip_23andMe v1|all of the SNPedia snps on the customized chip]]
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| − | Older posts (from 2007) related to the (extensive) press coverage received by 23andMe:
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| − | You can watch the founders explain their plan during this [http://www.youtube.com/watch?v=JdJHYK4Amcw youtube video].
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| − | Blog coverage has been extensive, you will find more information at [http://mndoci.com/blog/2007/11/19/your-personal-health-social-networking-x0-revisited-and-some-killer-video/ bbgm]
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| − | According to a story in Fortune, Warren Buffet and Jimmy Buffet submitted DNA tests for 23andMe. Approximately March 2007. [http://money.cnn.com/magazines/fortune/fortune_archive/2007/06/11/100060549/index.htm?section=magazines_fortune Fortune Magazine June 11 2007]
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| − | NY Times [http://www.nytimes.com/2007/05/29/technology/29google.html?_r=1&oref=slogin biography of] Anne Wojcicki
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| − | NY Times [http://www.nytimes.com/2007/05/23/technology/23google.html coverage of 23andMe]
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| − | a well written analysis of 23andMed from [http://www.bioarraynews.com/issues/7_32/features/141540-1.html bioarraynews] (login req)
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| − | Bio-IT World has announced the three keynote speakers for its sixth annual Bio-IT World Conference & Expo, to be held in Boston April 28-30, 2008).
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| − | The keynoters will be Linda Avey, co-founder of 23andMe; Joshua Boger, president & CEO of Vertex Pharmaceuticals; and John Reynders, CIO, Johnson & Johnson Life Sciences Division.
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| − | Linda Avey is the co-founder of 23andMe, the Bay Area consumer genomics start-up. She previously worked in sales and business development for Affymetrix and Perlegen Sciences. Prior to that, Avey had stints at Spotfire and Applied Biosystems. Avey founded 23andMe with Anne Wojcicki, wife of Google co-founder Sergey Brin (Google is also an investor in 23andMe). Partnering with Illumina, 23andMe will shortly unveil a consumer genotyping service offering individuals whole-genome analysis to learn about genealogy, ancestry, and medical issues. Avey will speak on Wednesday morning, April 30, 2008.
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| − | Various news sites reported on Oct-4-2007
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| − | 23andMe had raised an additional $9 million in funding.
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| − | investor include Google, Mohr Davidow Ventures, New Enterprise Associates, and Genentech.
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| − | [http://genomeboy.com/2007/10/15/accurate-shmaccurate/ genomeboy] found a few new details on [[23andMe]] and [[Navigenics]]
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| − | [http://flickr.com/search/?q=23andme&w=all photos] from Flickr..
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| − | ==Data==
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| − | Customers can now download their
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| − | [https://you.23andme.com/tools/data/download/ raw data]. Developers should use the [https://api.23andme.com/ API].
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| − | If you look here:
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| − | https://customercare.23andme.com/hc/en-us/articles/219202567-What-do-I-need-to-know-about-transitioning-to-the-new-23andMe-
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| − | and then click on the link for 'Locked Reports', you'll go to here:
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| − | https://customercare.23andme.com/hc/en-us/articles/219202567-What-do-I-need-to-know-about-transitioning-to-the-new-23andMe-#locked_report
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| − | which eventually leads to the following:
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| − | To opt in to a locked report, click the name of the report and read general information about the condition.
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| − | The report will tell you how to make your results visible. Once you have opted in to the report, it will shuffle itself,
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| − | alphabetically, within the appropriate list. Note that once you opted in and unlocked a locked report, it cannot be re-locked.
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| − | The raw data is delivered in a compressed ZIP file (about 5 MB).
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| − | Sample raw data is available from SNPedia, for example for [[User:Dichro|Mikolaj_Habryn]], ([http://sites.google.com/a/rcpt.to/dichro/Home/genotyping/genome_Mikolaj_Habryn_20080522154706.zip?attredirects=0 download ]).
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| − | unzip -t genome_Mikolaj_Habryn_20080522154706.zip
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| − | Archive: genome_Mikolaj_Habryn_20080522154706.zip
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| − | testing: genome_Mikolaj_Habryn_20080522154706.txt OK
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| − | No errors detected in compressed data of genome_Mikolaj_Habryn_20080522154706.zip.
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| − | SNP data is reported in an
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| − | [http://en.wikipedia.org/wiki/ASCII ASCII] file containing
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| − | [http://en.wikipedia.org/wiki/Comma-separated_values comma-separated values] ([http://en.wikipedia.org/wiki/Tab_key TAB-separated] to be precise).
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| − | unzip -c genome_Mikolaj_Habryn_20080522154706.zip genome_Mikolaj_Habryn_20080522154706.txt | head -25
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| − | Archive: genome_Mikolaj_Habryn_20080522154706.zip
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| − | inflating: genome_Mikolaj_Habryn_20080522154706.txt
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| − | # This data file generated by 23andMe at: Thu May 22 15:47:06 2008
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| − | #
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| − | # Below is a text version of your data. Fields are TAB-separated
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| − | # Each line corresponds to a single SNP. For each SNP, we provide its identifier
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| − | # (an rsid or an internal id), its location on the reference human genome, and the
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| − | # genotype call oriented with respect to the plus strand on the human reference
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| − | # sequence. We are using reference human assembly build 36. Note that it is possible
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| − | # that data downloaded at different times may be different due to ongoing improvements
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| − | # in our ability to call genotypes.
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| − | #
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| − | # More information on reference human assembly build 36:
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| − | # http://www.ncbi.nlm.nih.gov/projects/mapview/map_search.cgi?taxid=9606&build=36
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| − | #
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| − | # rsid chromosome position genotype
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| − | rs3094315 1 742429 AG
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| − | rs12562034 1 758311 AG
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| − | rs3934834 1 995669 CC
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| − | rs9442372 1 1008567 AG
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| − | rs3737728 1 1011278 AG
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| − | rs11260588 1 1011521 GG
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| − | rs6687776 1 1020428 CC
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| − | rs9651273 1 1021403 AG
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| − | rs4970405 1 1038818 AA
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| − | ...
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| − | The fourth column of the SNP data contains the actual genotype (AG, CC, CC and so on). Further analysis of this data set reveals that 23andMe (unlike deCODEme) reports a very small number of deletions and insertions, coded as II (occurs 30 times), DD (occurs 28 times), and DI (occurs 3 times). The actual numbers can be calculated like this (in a Unix command shell):
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| − | unzip -c genome_Mikolaj_Habryn_20080522154706.zip genome_Mikolaj_Habryn_20080522154706.txt |\
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| − | awk 'NF==4{print $4}' | sort | uniq -c | sort -n
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| − | 3 DI
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| − | 28 DD
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| − | 30 II
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| − | 234 AT
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| − | 354 CG
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| − | 5491 --
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| − | 15980 GT
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| − | 16301 AC
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| − | 70180 CT
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| − | 70451 AG
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| − | 93323 AA
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| − | 94030 TT
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| − | 105381 GG
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| − | 105994 CC
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| − | ==patents==
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| − | genotyping
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| − | http://www.google.com/patents/US8428886
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| − | [[rs10513789]]
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| − | http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,187,811&OS=8,187,811&RS=8,187,811
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| − | https://www.google.com/search?tbo=p&tbm=pts&hl=en&q=inassignee:%2223Andme,+Inc.%22
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| − | http://www.reddit.com/r/23andme/comments/1o9n80/latest_23andme_processing_times_as_of_101113/
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