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Celiac disease

From SNPedia
(Redirected from Gluten intolerance)

Celiac disease, also known as gluten intolerance, is an autoimmune disorder of genetically predisposed individuals, provoked by gluten proteins in wheat and related foods. Wikipedia

SNPs associated with celiac disease:

Although the HLA-DQ2 and DQ8 haplotypes are associated with gluten intolerance, as a 2010 blog post indicates, the frequency of these haplotypes (20-30%) is much higher than the frequency of celiac disease (~1%), so perhaps the primary value of SNP testing in this context is to rule out the likelihood of gluten intolerance. In other words, if you are among the 70-80% of individuals who do not carry HLA-DQ2 and/or DQ8 haplotypes, you are quite likely (> 95%) to tolerate gluten and to not be at risk for celiac disease.