Gs298
From SNPedia
| Gs298 | |
|---|---|
| Magnitude | 2.5 |
| Repute | Bad |
| Summary | Increased surveillance for colorectal cancer recommended |
| Criteria | Gs298/criteria |
This genoset detects the ~10% of the population having either 3 or more risk alleles, or 3 at-risk genotypes, at 3 SNPs associated with colorectal cancer; this puts a person at ~3 fold higher risk than a person with 0 risk alleles, and on a par with someone who has a first degree relative with colorectal cancer. As a result, individuals with this genoset might benefit from colorectal detection based either on fecal immunochemical testing or colonoscopy every 5 years starting as early as age 40, according to one study.10.1038/ejhg.2015.72
The 3 SNPs and their risk alleles are:
- rs16892766(C)
- rs4779584(T)
- rs58920878(G)
