rs10380

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	0	common in complete genomics

Make rs10380(C;T)

Make rs10380(T;T)

Reference

GRCh38 38.1/141

Chromosome

5

Position

7897078

Gene

MTRR

is a	snp
is	mentioned by
dbSNP	rs10380
dbSNP (classic)	rs10380
ClinGen	rs10380
ebi	rs10380
HLI	rs10380
Exac	rs10380
Gnomad	rs10380
Varsome	rs10380
LitVar	rs10380
Map	rs10380
PheGenI	rs10380
Biobank	rs10380
1000 genomes	rs10380
hgdp	rs10380
ensembl	rs10380
geneview	rs10380
scholar	rs10380
google	rs10380
pharmgkb	rs10380
gwascentral	rs10380
openSNP	rs10380
23andMe	rs10380
SNPshot	rs10380
SNPdbe	rs10380
MSV3d	rs10380
GWAS Ctlg	rs10380

GMAF

0.1901

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

[PMID 18515090] pancreatic cancer 702 cases and 785 controls

• rs162049 P = .0018; OR, 1.33; 95% CI: 1.11-1.60
• rs10380 (His595Tyr) P = .0063; OR, 1.45; 95% CI: 1.11-1.88

[PMID 19493349] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

[PMID 21211571] MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic

[PMID 19064578] No association of single nucleotide polymorphisms in one-carbon metabolism genes with prostate cancer risk.

[PMID 20445798] Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.

[PMID 22957669] Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA

ClinVar
Risk	rs10380(T;T)
Alt	rs10380(T;T)
Reference	Rs10380(C;C)
Significance	Non-pathogenic
Disease	not specified Gastrointestinal stromal tumor Disorders of Intracellular Cobalamin Metabolism
Variation	info
Gene	MTRR
CLNDBN	not specified Gastrointestinal stromal tumor Disorders of Intracellular Cobalamin Metabolism
Reversed	0
HGVS	NC_000005.9:g.7897191C>T
CLNSRC	UniProtKB (protein)
CLNACC	RCV000126880.2, RCV000144924.1, RCV000302798.1,