rs10509305

plus

Geno	Mag	Summary
(A;A)	0	common in clinvar
(A;C)	1.5	carrier for pre-eclampsia associated variant
(C;C)	3	fetuses with this genotype may cause maternal pre-eclampsia

Reference

GRCh38 38.1/141

Chromosome

10

Position

68885620

Gene

STOX1

is a	snp
is	mentioned by
dbSNP	rs10509305
dbSNP (classic)	rs10509305
ClinGen	rs10509305
ebi	rs10509305
HLI	rs10509305
Exac	rs10509305
Gnomad	rs10509305
Varsome	rs10509305
LitVar	rs10509305
Map	rs10509305
PheGenI	rs10509305
Biobank	rs10509305
1000 genomes	rs10509305
hgdp	rs10509305
ensembl	rs10509305
geneview	rs10509305
scholar	rs10509305
google	rs10509305
pharmgkb	rs10509305
gwascentral	rs10509305
openSNP	rs10509305
23andMe	rs10509305
SNPshot	rs10509305
SNPdbe	rs10509305
MSV3d	rs10509305
GWAS Ctlg	rs10509305

GMAF

0.1437

Max Magnitude

3

rs10509305, also known as Glu608Asp or E608D, is a variant in the storkhead box 1 STOX1 gene.

In [PMID 15806103] and subsequent publications, it is reported that when fetuses are rs10509305(C;C), their mothers are likely to have pre-eclampsia and possibly also pregnancy-induced hypertension.

?

(A;A) (A;C) (C;C)

28

OMIM	609397
Desc
Variant	0002
Related	also

ClinVar
Risk	Rs10509305(C;C)
Alt	Rs10509305(C;C)
Reference	Rs10509305(A;A)
Significance	Pathogenic
Disease	Preeclampsia/eclampsia 4
Variation	info
Gene	STOX1
CLNDBN	Preeclampsia/eclampsia 4
Reversed	0
HGVS	NC_000010.10:g.70645376A>C
CLNSRC	OMIM Allelic Variant UniProtKB (protein)
CLNACC	RCV000001790.2,