rs10895068
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.5 | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| (A;G) | 1.5 | 2.5x increased odds of breast cancer among hormone-using postmenopausal women |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 101129483 |
| Gene | PGR, PGR-AS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10895068 |
| dbSNP (classic) | rs10895068 |
| ClinGen | rs10895068 |
| ebi | rs10895068 |
| HLI | rs10895068 |
| Exac | rs10895068 |
| Gnomad | rs10895068 |
| Varsome | rs10895068 |
| LitVar | rs10895068 |
| Map | rs10895068 |
| PheGenI | rs10895068 |
| Biobank | rs10895068 |
| 1000 genomes | rs10895068 |
| hgdp | rs10895068 |
| ensembl | rs10895068 |
| geneview | rs10895068 |
| scholar | rs10895068 |
| rs10895068 | |
| pharmgkb | rs10895068 |
| gwascentral | rs10895068 |
| openSNP | rs10895068 |
| 23andMe | rs10895068 |
| SNPshot | rs10895068 |
| SNPdbe | rs10895068 |
| MSV3d | rs10895068 |
| GWAS Ctlg | rs10895068 |
| GMAF | 0.02066 |
| Max Magnitude | 1.5 |
rs10895068, also known as +331G/A, is a SNP in the progesterone receptor PGR gene.
A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one rs10895068(A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing breast cancer. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for breast cancer if they were never postmenopausal hormone users.[PMID 19462450
]
2013 meta-analysis suggested association of weak effect with female reproductive (breast, endometrial and ovarian) cancer for A allele (A: OR = 1.063, 95% CI = 1.001-1.129; AA+AG: OR = 1.067, 95% CI = 1.002-1.136). A 2014 meta-analysis that looked only for association with ovarian cancer specifically found no significant association between rs10895068 and ovarian cancer - despite the study title claiming otherwise.
[PMID 24197980] Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.
[PMID 23349706] Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.
[PMID 20076999] No association between a progesterone receptor gene promoter polymorphism (+331G>A) and breast cancer risk in Caucasian women: evidence from a literature-based meta-analysis
[PMID 20586553] Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis
[PMID 21086036] Association of progesterone receptor polymorphism with idiopathic recurrent pregnancy loss in Taiwanese Han population
[PMID 21148628] Progesterone receptor gene variants and risk of endometrial cancer
| ? | (A;G) (G;G) | |
|---|---|---|
|
| ||
[PMID 22121098] Worldwide distribution of allelic variation at the progesterone receptor locus and the incidence of female reproductive cancers
[PMID 16614108] Association of the progesterone receptor gene with breast cancer risk: a single-nucleotide polymorphism tagging approach.
[PMID 16985038] PGR +331 A/G and increased risk of epithelial ovarian cancer.
[PMID 17592773] Progesterone receptor polymorphisms and risk of breast cancer: results from two Australian breast cancer studies.
[PMID 18219286] Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis.
[PMID 18592033] Sex steroid-related candidate genes in psychiatric disorders.
[PMID 18628428] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 19382201] Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population.
[PMID 19555469] A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.
[PMID 26694100] Obesity-related known and candidate SNP markers can significantly change affinity of TATA-binding protein for human gene promoters.
[PMID 31115963] The implication of single-nucleotide polymorphisms in ovarian hyperstimulation syndrome.
[PMID 33000295] Genetic variations in estrogen and progesterone pathway genes in preeclampsia patients and controls in Bavaria.
