rs11178997
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 0 |
| Make rs11178997(A;A) |
| Make rs11178997(A;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 71938373 |
| Gene | TPH2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11178997 |
| dbSNP (classic) | rs11178997 |
| ClinGen | rs11178997 |
| ebi | rs11178997 |
| HLI | rs11178997 |
| Exac | rs11178997 |
| Gnomad | rs11178997 |
| Varsome | rs11178997 |
| LitVar | rs11178997 |
| Map | rs11178997 |
| PheGenI | rs11178997 |
| Biobank | rs11178997 |
| 1000 genomes | rs11178997 |
| hgdp | rs11178997 |
| ensembl | rs11178997 |
| geneview | rs11178997 |
| scholar | rs11178997 |
| rs11178997 | |
| pharmgkb | rs11178997 |
| gwascentral | rs11178997 |
| openSNP | rs11178997 |
| 23andMe | rs11178997 |
| SNPshot | rs11178997 |
| SNPdbe | rs11178997 |
| MSV3d | rs11178997 |
| GWAS Ctlg | rs11178997 |
| GMAF | 0.1446 |
| Max Magnitude | 0 |
rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission
paper Association with and bipolar disorder in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001
[PMID 17568567] rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain.
paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors for major depression
pdf paper associated with bipolar disorder
[PMID 17905754] Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for bipolar disorder in a study of 883 Russian patients.
[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals
[PMID 22483952] Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms
[PMID 16116490] Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.
[PMID 17015812] Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.
[PMID 18782386
] Tryptophan hydroxylase 2 gene and alcohol use among college students.
[PMID 18797398] Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.
[PMID 20126463] Alternative splicing and extensive RNA editing of human TPH2 transcripts.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 22392150] Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.
[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.
[PMID 25014617] TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
[PMID 31291234] Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD.
