rs4570625

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	1.5	maybe: higher scores on anxiety-related personality traits; greater placebo response
(G;T)		normal
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

12

Position

71938143

Gene

TPH2

is a	snp
is	mentioned by
dbSNP	rs4570625
dbSNP (classic)	rs4570625
ClinGen	rs4570625
ebi	rs4570625
HLI	rs4570625
Exac	rs4570625
Gnomad	rs4570625
Varsome	rs4570625
LitVar	rs4570625
Map	rs4570625
PheGenI	rs4570625
Biobank	rs4570625
1000 genomes	rs4570625
hgdp	rs4570625
ensembl	rs4570625
geneview	rs4570625
scholar	rs4570625
google	rs4570625
pharmgkb	rs4570625
gwascentral	rs4570625
openSNP	rs4570625
23andMe	rs4570625
SNPshot	rs4570625
SNPdbe	rs4570625
MSV3d	rs4570625
GWAS Ctlg	rs4570625

GMAF

0.3632

Max Magnitude

1.5

?	(G;G) (G;T) (T;T)	28

rs4570625, also known as G-703T, is a SNP in the tryptophan hydroxylase 2 TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:

• [PMID 16146581] rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder

• rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission

• [PMID 19052197] rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.

g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not

[PMID 19132526] panic disorder with a possible gender-dependent effect

OMIM	143465
Desc	ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
Variant
Related	also

OMIM	607478
Desc	TRYPTOPHAN HYDROXYLASE 2; TPH2
Variant
Related	also

[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder

[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals

[PMID 20331984] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes

OMIM	613003
Desc
Variant
Related	also

[PMID 21396719] Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia

[PMID 22693556] TPH2 Gene Polymorphisms and Major Depression – A Meta-Analysis

[PMID 22698518] Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients

[PMID 16116490] Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

[PMID 17176491] Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

[PMID 17176492] Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

[PMID 17346350] Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

[PMID 17568567] Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.

[PMID 17892388] Genetic variation of serotonin function and cognitive control.

[PMID 18782386] Tryptophan hydroxylase 2 gene and alcohol use among college students.

[PMID 19077664] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

[PMID 19361870] TPH2 gene variants and anxiety during alcohol detoxification outcome.

[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 20126463] Alternative splicing and extensive RNA editing of human TPH2 transcripts.

[PMID 20938755] Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.

[PMID 21172166] Pharmacogenetics of antidepressant response.

[PMID 21418063] Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.

[PMID 22322887] Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

[PMID 22392150] Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.

[PMID 22868061] The role of serotonergic genes and environmental stress on the development of depressive symptoms and neuroticism

[PMID 24304270] Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants

[PMID 24458851] Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches

[PMID 22655589] Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics.

[PMID 22835848] Tryptophan hydroxylase 2 gene polymorphisms and poststroke anxiety disorders.

[PMID 23628433] Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population.

[PMID 26013962] Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users

[PMID 26232682] Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psychopathological symptoms

[PMID 27069689] Serotonin-Related Gene Polymorphisms and Asymptomatic Neurocognitive Impairment in HIV-Infected Alcohol Abusers

[PMID 30309244] Association of Fatigue With TPH2 Genetic Polymorphisms in Women With Irritable Bowel Syndrome.