rs11649743

plus

Geno	Mag	Summary
(A;A)	2.5	Lower prostate cancer risk?

Make rs11649743(A;G)

Make rs11649743(G;G)

Reference

GRCh38 38.1/141

Chromosome

17

Position

37714971

Gene	HNF1B, LOC105371754

is a	snp
is	mentioned by
dbSNP	rs11649743
dbSNP (classic)	rs11649743
ClinGen	rs11649743
ebi	rs11649743
HLI	rs11649743
Exac	rs11649743
Gnomad	rs11649743
Varsome	rs11649743
LitVar	rs11649743
Map	rs11649743
PheGenI	rs11649743
Biobank	rs11649743
1000 genomes	rs11649743
hgdp	rs11649743
ensembl	rs11649743
geneview	rs11649743
scholar	rs11649743
google	rs11649743
pharmgkb	rs11649743
gwascentral	rs11649743
openSNP	rs11649743
23andMe	rs11649743
SNPshot	rs11649743
SNPdbe	rs11649743
MSV3d	rs11649743
GWAS Ctlg	rs11649743

GMAF

0.2025

Max Magnitude

2.5

?

(A;A) (A;G) (G;G)

28

[PMID 19998368 ] rs11649743 identified as one of three HNF1B gene SNPs associated with decreased risk for prostate cancer in two large prospective studies

[PMID 18758462 ] prostate cancer rs4430796 and rs11649743 in multiple populations, with P = 1.7 x 10(-9)

OMIM	611955
Desc	PROSTATE CANCER, HEREDITARY, 11; HPC11
Variant
Related	also

[PMID 21576123 ] Large-scale fine mapping of the HNF1B locus and prostate cancer risk

[PMID 19117981 ] Sequence variants at 22q13 are associated with prostate cancer risk.

[PMID 19168595 ] Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.

[PMID 19318432 ] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.

[PMID 19434657 ] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.

[PMID 19549807 ] Prostate cancer risk associated loci in African Americans.

[PMID 20039378 ] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.

[PMID 20569440 ] Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer.

[PMID 21390317 ] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.

[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]