rs12469063

plus

Geno	Mag	Summary
(A;A)	1	Normal risk of developing restless legs syndrome
(A;G)	1.5	Slightly increased risk of developing restless legs syndrome
(G;G)	2	Increased risk of developing restless legs syndrome

Reference

GRCh38 38.1/141

Chromosome

2

Position

66537176

Gene

MEIS1

is a	snp
is	mentioned by
dbSNP	rs12469063
dbSNP (classic)	rs12469063
ClinGen	rs12469063
ebi	rs12469063
HLI	rs12469063
Exac	rs12469063
Gnomad	rs12469063
Varsome	rs12469063
LitVar	rs12469063
Map	rs12469063
PheGenI	rs12469063
Biobank	rs12469063
1000 genomes	rs12469063
hgdp	rs12469063
ensembl	rs12469063
geneview	rs12469063
scholar	rs12469063
google	rs12469063
pharmgkb	rs12469063
gwascentral	rs12469063
openSNP	rs12469063
23andMe	rs12469063
SNPshot	rs12469063
SNPdbe	rs12469063
MSV3d	rs12469063
GWAS Ctlg	rs12469063

GMAF

0.1928

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

rs12469063, a SNP located in the MEIS1 gene, has been linked to restless legs syndrome, a common sleep disorder, with an overall odds ratio of 1.78 (CI: 1.52-2.10) for the (G) risk allele. [PMID 17637780]

The association from this region that gives the highest association to restless legs syndrome, however, is a haplotype consisting of the rs6710341(A) and rs12469063(G) alleles. This haplotype gives rise to an odds ratio of 2.75 (CI: 2.23-3.41). [PMID 17637780]

[PMID 19223043] Exploring the genetic link between RLS and ADHD

OMIM	612853
Desc
Variant
Related	also

[PMID 19126776 ] MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.

[PMID 19279021 ] Replication of restless legs syndrome loci in three European populations.

[PMID 20396431 ] Genotyping sleep disorders patients.

[PMID 25142570 ] Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD