|(G;G)||1.5||May indicate increased susceptibility to schizophrenia|
anxiety-related personality traits, ADHD, schizophrenia
part of a three marker haplotype rs737865-rs4680-rs165599
epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes
[PMID 17547583] is associated with bipolar disorder and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.
[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan
[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
[PMID 19605537] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
[PMID 20586531] The catechol-O-methyl-transferase gene in tardive dyskinesia
[PMID 21595525] Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder
[PMID 21934638] A COMT gene haplotype associated with methamphetamine abuse
[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
[PMID 15570503] No evidence for gender-specific sharing of COMT alleles in schizophrenia
[PMID 12802784] A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
[PMID 15098000] COMT haplotypes suggest P2 promoter region relevance for schizophrenia.
[PMID 15124004] Variants in the catechol-o-methyltransferase (COMT) gene are associated with schizophrenia in Irish high-density families.
[PMID 15457404] Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain.
[PMID 15505638] Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.
[PMID 15635644] A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD).
[PMID 15931594] An entropy-based statistic for genomewide association studies.
[PMID 15956988] COMT polymorphisms and anxiety-related personality traits.
[PMID 15962707] The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia.
[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
[PMID 16232322] COMT genetic variation confers risk for psychotic and affective disorders: a case control study.
[PMID 16380905] Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
[PMID 16483362] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.
[PMID 16786032] Impact of complex genetic variation in COMT on human brain function.
[PMID 16816420] Nonlinear tests for genomewide association studies.
[PMID 17006672] Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.
[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
[PMID 17466074] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
[PMID 17630406] Dopamine genes and schizophrenia: case closed or evidence pending?
[PMID 17707347] Genetic variation in catechol-O-methyltransferase: effects on working memory in schizophrenic patients, their siblings, and healthy controls.
[PMID 17949513] Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS.
[PMID 17961261] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
[PMID 18021915] Genetics and smoking cessation improving outcomes in smokers at risk.
[PMID 18081002] Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials.
[PMID 18384078] Association study of candidate variants of COMT with neuroticism, anxiety and depression.
[PMID 18436194] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
[PMID 18466879] Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample.
[PMID 18574484] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
[PMID 18704099] Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 19071221] Impact of interacting functional variants in COMT on regional gray matter volume in human brain.
[PMID 19329282] Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.
[PMID 19365560] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
[PMID 19721400] Association between COMT gene and Chinese male schizophrenic patients with violent behavior.
[PMID 20080926] The influence of 5-HTT and COMT genotypes on verbal fluency in ecstasy users.
[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
[PMID 20667552] Catechol-o-methyltransferase gene modulation on suicidal behavior and personality traits: review, meta-analysis and association study.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].
[PMID 21609749] Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intellectual disability.
[PMID 21788083] Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
[PMID 24320736] Role of single nucleotide polymorphisms in estrogen-metabolizing enzymes and susceptibility to uterine leiomyoma in Han Chinese: A case-control study
[PMID 22713126] COMT polymorphisms as predictors of cognitive dysfunction during manic and mixed episodes in bipolar I disorder.
[PMID 23178897] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
[PMID 23332465] Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets
[PMID 23598060] Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia
[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.
[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.
[PMID 28273278] Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls.
[PMID 29559808] Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.
[PMID 30165727] Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.
[PMID 33588721] Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment.