We have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. [PMID 15098000]
may affect non-Hodgkin lymphoma, anxiety-related personality traits
Also mentioned in these PMIDs
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[PMID 15931594] An entropy-based statistic for genomewide association studies.
[PMID 16027741] Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
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[PMID 16483362] The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression.
[PMID 16525418] Association of the Val158Met catechol O-methyltransferase genetic polymorphism with panic disorder.
[PMID 16816420] Nonlinear tests for genomewide association studies.
[PMID 16837108] Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
[PMID 17363961] Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.
[PMID 17427186] Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study.
[PMID 17466074] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
[PMID 17482701] No associations exist between five functional polymorphisms in the catechol-O-methyltransferase gene and schizophrenia in a Japanese population.
[PMID 17630406] Dopamine genes and schizophrenia: case closed or evidence pending?
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[PMID 18436194] Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes.
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[PMID 29330410] The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.
[PMID 30692067] [Postpartum depression: association with genetic polymorphisms of noradrenaline metabolic enzymes and the risk factors].
[PMID 30706571] A candidate gene study of risk for dementia in older, post-menopausal women: Results from the Women's Health Initiative Memory Study.