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From SNPedia

Geno Mag Summary
(G;G) ~1.7x increased obesity risk
(G;T) ~1.3x increased obesity risk
(T;T) 0 normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs17817449
1000 genomesrs17817449
GWAS Ctlgrs17817449
Max Magnitude0
? (G;G) (G;T) (T;T) 28

Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs17817449, although this SNP is one of co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied of FTO SNPs, rs9930506. [PMID 17658951OA-icon.png]

[PMID 18316358] A study of 900+ Quebec individuals reported that rs17817449 was associated with BMI (p=0.0014), weight (p=0.0059) and waist circumference (p=0.0021) under an additive model, and in addition, influenced fasting insulin (p=0.011) and HOMA-IR (p=0.038).

  • Note: The three FTO SNPs, rs1421085, rs17817449, and rs9939609, are in strong linkage disequilibrium (pairwise r2>0.97), and there are two primary haplotypes, C-G-A (42.0 %) and T-T-T (55.5 %).

[PMID 18719664] This SNP is also associated with adult obesity in Mexicans.

[PMID 18551112] rs1421085(C) and rs17817449(G) significantly associated with increased BMI. Our results suggest that FTO may be one of the worldwide obesity-risk genes.

[PMID 19278366] A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females Czech post-MONICA and 3PMFs studies.

[PMID 19322589OA-icon.png] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study


[PMID 20717169OA-icon.png] FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males

[PMID 20945952OA-icon.png] FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study

GWAS snp
PMID [PMID 21552555OA-icon.png]
Title A genome-wide association study on obesity and obesity-related traits.
Risk Allele
P-val 2E-12
Odds Ratio None None

[PMID 20945953] Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms

[PMID 22030988] FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain

[PMID 17928949] FTO polymorphisms in oceanic populations.

[PMID 18218107OA-icon.png] FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.

[PMID 18256137OA-icon.png] Regulation of Fto/Ftm gene expression in mice and humans.

[PMID 18487448OA-icon.png] Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.

[PMID 18599522OA-icon.png] FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.

[PMID 18647953OA-icon.png] Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

[PMID 18833210] The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study.

[PMID 19265514OA-icon.png] FTO gene variation and measures of body mass in an African population.

[PMID 20080751OA-icon.png] Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.

[PMID 20362563] A FTO variant and risk of acute coronary syndrome.

[PMID 20381893OA-icon.png] The genetics of obesity: FTO leads the way.

[PMID 20404173OA-icon.png] A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

[PMID 20442772OA-icon.png] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

[PMID 20502638OA-icon.png] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

[PMID 21102551OA-icon.png] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

[PMID 21317302OA-icon.png] FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans.

[PMID 21318054OA-icon.png] Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents.

[PMID 21788373OA-icon.png] The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.

[PMID 21919686] Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population.

[PMID 22157232] Lack of an association between three tagging SNPs within the FTO gene and smoking behavior.

[PMID 22187296] Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention.

[PMID 22614171OA-icon.png] Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

[PMID 23136261OA-icon.png] Fat mass and obesity gene and cognitive decline: The Atherosclerosis Risk in Communities Study

[PMID 24106974] Association between fat mass and obesity-associated (FTO) gene and hip fracture susceptibility

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele T
P-val 6E-7
Odds Ratio 1.09 [1.05-1.12]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele T
P-val 6E-14
Odds Ratio 1.08 [1.05-1.1]

[PMID 22503908] Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study.

[PMID 23201545] FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention.

[PMID 23771786] Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence.

[PMID 26726774OA-icon.png] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.

[PMID 27196486OA-icon.png] FTO rs 9939609 SNP Is Associated With Adiponectin and Leptin Levels and the Risk of Obesity in a Cohort of Romanian Children Population.

[PMID 29154870] The FTO variant is associated with chronic complications of diabetes mellitus in Czech population.

[PMID 30408245] The FTO polymorphism influences the risk of rejection in heart transplant patients.

[PMID 30621571] The Potential Implication of FTO rs17817449 Gene Polymorphism On BMI Mediated Risk For Type2 Diabetes Among Obese Egyptian Children And Adolescents.