rs1800750
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | higher acute otitis risk | |
| (A;G) | normal risk | |
| (G;G) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 31575186 |
| Gene | TNF |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1800750 |
| dbSNP (classic) | rs1800750 |
| ClinGen | rs1800750 |
| ebi | rs1800750 |
| HLI | rs1800750 |
| Exac | rs1800750 |
| Gnomad | rs1800750 |
| Varsome | rs1800750 |
| LitVar | rs1800750 |
| Map | rs1800750 |
| PheGenI | rs1800750 |
| Biobank | rs1800750 |
| 1000 genomes | rs1800750 |
| hgdp | rs1800750 |
| ensembl | rs1800750 |
| geneview | rs1800750 |
| scholar | rs1800750 |
| rs1800750 | |
| pharmgkb | rs1800750 |
| gwascentral | rs1800750 |
| openSNP | rs1800750 |
| 23andMe | rs1800750 |
| SNPshot | rs1800750 |
| SNPdbe | rs1800750 |
| MSV3d | rs1800750 |
| GWAS Ctlg | rs1800750 |
| GMAF | 0.01331 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1800750, a SNP located at position -376 of the TNF gene, has been linked to increased risk for recurrent acute otitis in a study of 348 children. The (adjusted) odds ratio is 3.06 for (G;G) genotypes (p=0.07).[PMID 17908769]
[PMID 19559392
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[PMID 18194515] Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19143814] Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.
[PMID 19167443] Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.
[PMID 19281305] Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19619703] Association of genetic variants with the metabolic syndrome in 20,806 white women: The Women's Health Genome Study.
[PMID 20078877] Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.
[PMID 20459687] Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
[PMID 21385363] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
[PMID 24151497] Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria
[PMID 22711844] SNPs in the TNF-alpha gene promoter associated with Behcet's disease in Moroccan patients.
[PMID 22808100] Functional differences exist between TNFalpha promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.
[PMID 26448013] High Incidence of Malaria Along the Sino-Burmese Border Is Associated With Polymorphisms of CR1, IL-1A, IL-4R, IL-4, NOS, and TNF, But Not With G6PD Deficiency
[PMID 29497291] TNF promoter polymorphisms are associated with genetic susceptibility in COPD secondary to tobacco smoking and biomass burning.
