rs1802059

plus

Geno	Mag	Summary
(G;G)	0	common in clinvar

Make rs1802059(A;A)

Make rs1802059(A;G)

Reference

GRCh38 38.1/141

Chromosome

5

Position

7897206

Gene

MTRR

is a	snp
is	mentioned by
dbSNP	rs1802059
dbSNP (classic)	rs1802059
ClinGen	rs1802059
ebi	rs1802059
HLI	rs1802059
Exac	rs1802059
Gnomad	rs1802059
Varsome	rs1802059
LitVar	rs1802059
Map	rs1802059
PheGenI	rs1802059
Biobank	rs1802059
1000 genomes	rs1802059
hgdp	rs1802059
ensembl	rs1802059
geneview	rs1802059
scholar	rs1802059
google	rs1802059
pharmgkb	rs1802059
gwascentral	rs1802059
openSNP	rs1802059
23andMe	rs1802059
SNPshot	rs1802059
SNPdbe	rs1802059
MSV3d	rs1802059
GWAS Ctlg	rs1802059

GMAF

0.2489

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

Yasko Methylation Methionine synthase, coded by the MTR gene, has a B12 attached to it. The Methionine synthase takes a methyl group from methyl folate and attaches it to its B12, then it attaches it to a molecule of homocysteine, turning it into methionine, which in turn becomes SAMe. After 1000-2000 times doing this, the B12 gets turned into a useless form, and MTRR turns the B12 back into the useful form so that the molecule of MTR can keep working. The MTRR mutations make this enzyme less active, suggesting a need for more B12.

[PMID 19493349 ] 118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

[PMID 20445798 ] Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women.

ClinVar
Risk	rs1802059(A;A)
Alt	rs1802059(A;A)
Reference	Rs1802059(G;G)
Significance	Non-pathogenic
Disease	not specified Disorders of Intracellular Cobalamin Metabolism
Variation	info
Gene	MTRR
CLNDBN	not specified Disorders of Intracellular Cobalamin Metabolism
Reversed	0
HGVS	NC_000005.9:g.7897319G>A
CLNSRC	ClinVar GeneDx
CLNACC	RCV000126882.3, RCV000390684.1,