rs2486758
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.2 | Slightly higher prostate cancer risk; poorer response to AA/P treatment |
| (C;T) | 2 | Slightly higher prostate cancer risk; poorer response to AA/P treatment |
| (T;T) | 2 | Slightly lower prostate cancer risk; better response to AA/P treatment |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 102837723 |
| Gene | CYP17A1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2486758 |
| dbSNP (classic) | rs2486758 |
| ClinGen | rs2486758 |
| ebi | rs2486758 |
| HLI | rs2486758 |
| Exac | rs2486758 |
| Gnomad | rs2486758 |
| Varsome | rs2486758 |
| LitVar | rs2486758 |
| Map | rs2486758 |
| PheGenI | rs2486758 |
| Biobank | rs2486758 |
| 1000 genomes | rs2486758 |
| hgdp | rs2486758 |
| ensembl | rs2486758 |
| geneview | rs2486758 |
| scholar | rs2486758 |
| rs2486758 | |
| pharmgkb | rs2486758 |
| gwascentral | rs2486758 |
| openSNP | rs2486758 |
| 23andMe | rs2486758 |
| SNPshot | rs2486758 |
| SNPdbe | rs2486758 |
| MSV3d | rs2486758 |
| GWAS Ctlg | rs2486758 |
| GMAF | 0.1892 |
| Max Magnitude | 2.2 |
rs2486758 represents a variant in the CYP17A1 gene located in the intergenic region 5' to, or perhaps in, the promoter region.
The minor allele, rs2486758(C), has been associated with the following:
- Slightly increased risk for prostate cancer, including in a meta-analysis [PMID 21656827]
- Poorer response to treatment of metastatic castration-resistant prostate cancer by AA/P (abiraterone acetate plus prednisone).[PMID 27409606
]
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 22419734] Genetic Polymorphism CYP17 rs2486758 and Metabolic Risk Factors Predict Daily Salivary 17?-Estradiol Concentration in Healthy Premenopausal Norwegian Women. The EBBA-I Study
[PMID 18006912] CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).
[PMID 18505952
] Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
[PMID 19015200] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.
[PMID 19567509] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
[PMID 20411041] Common Variation in the CYP17A1 and IFIT1 Genes on Chromosome 10 Does Not Contribute to the Risk of Endometriosis.
[PMID 21229561] CYP17 gene polymorphisms and prostate cancer risk: A meta-analysis based on 38 independent studies.
[PMID 21656827] CYP17 gene polymorphisms and prostate cancer risk: a meta-analysis based on 38 independent studies.
[PMID 27409606] Common Genetic Variation in CYP17A1 and Response to Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer.
