rs2834167

plus

Geno	Mag	Summary
(A;A)	2.1	2.67x increased risk for systemic sclerosis
(A;G)	0	normal
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

21

Position

33268483

Gene

IL10RB

is a	snp
is	mentioned by
dbSNP	rs2834167
dbSNP (classic)	rs2834167
ClinGen	rs2834167
ebi	rs2834167
HLI	rs2834167
Exac	rs2834167
Gnomad	rs2834167
Varsome	rs2834167
LitVar	rs2834167
Map	rs2834167
PheGenI	rs2834167
Biobank	rs2834167
1000 genomes	rs2834167
hgdp	rs2834167
ensembl	rs2834167
geneview	rs2834167
scholar	rs2834167
google	rs2834167
pharmgkb	rs2834167
gwascentral	rs2834167
openSNP	rs2834167
23andMe	rs2834167
SNPshot	rs2834167
SNPdbe	rs2834167
MSV3d	rs2834167
GWAS Ctlg	rs2834167

GMAF

0.3448

Max Magnitude

2.1

?

(A;A) (A;G) (G;G)

28

rs2834167 is a SNP in the interleukin-10 receptor 2 IL10RB gene.

In a study of Japanese patients, rs2834167(A;A) individuals were at increased risk for diffuse cutaneous systemic sclerosis (odds ratio 2.67, p = 0.0018).[PMID 18588853]

OMIM	123889
Desc
Variant	0001
Related	also

ClinVar
Risk	Rs2834167(G;G)
Alt	Rs2834167(G;G)
Reference	Rs2834167(A;A)
Significance	Other
Disease	Hepatitis b virus Inflammatory bowel disease not specified
Variation	info
Gene	IL10RB
CLNDBN	Hepatitis b virus, susceptibility to Inflammatory bowel disease not specified
Reversed	0
HGVS	NC_000021.8:g.34640788A>G
CLNSRC	OMIM Allelic Variant UniProtKB (protein)
CLNACC	RCV000018431.2, RCV000392488.1, RCV000455211.1,

[PMID 19604093 ] Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

[PMID 20811626 ] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21532858 ] Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.

[PMID 23096091] Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.

[PMID 23749100] IL-10RB rs2834167 (A/G) polymorphism is associated with the susceptibility to systemic lupus erythematosus: evidence from a study in Chinese Han population.

[PMID 25032264] Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease

[PMID 28785144 ] Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.

[PMID 30594267 ] Association of a PD-L2 Gene Polymorphism with Chronic Lymphatic Filariasis in a South Indian Cohort.