rs2952768

plus

Geno	Mag	Summary
(C;C)	1	less drug dependence, decreased effectiveness of analgesics
(C;T)	1	slightly less drug dependence, decreased effectiveness of analgesics
(T;T)	1	normal/slightly increased risk of drug dependence, normal effectiveness of analgesics

Reference

GRCh38 38.1/141

Chromosome

2

Position

207629510

is a	snp
is	mentioned by
dbSNP	rs2952768
dbSNP (classic)	rs2952768
ClinGen	rs2952768
ebi	rs2952768
HLI	rs2952768
Exac	rs2952768
Gnomad	rs2952768
Varsome	rs2952768
LitVar	rs2952768
Map	rs2952768
PheGenI	rs2952768
Biobank	rs2952768
1000 genomes	rs2952768
hgdp	rs2952768
ensembl	rs2952768
geneview	rs2952768
scholar	rs2952768
google	rs2952768
pharmgkb	rs2952768
gwascentral	rs2952768
openSNP	rs2952768
23andMe	rs2952768
SNPshot	rs2952768
SNPdbe	rs2952768
MSV3d	rs2952768
GWAS Ctlg	rs2952768

GMAF

0.3581

Max Magnitude

1

?

(C;C) (C;T) (T;T)

28

Genome-wide association study identifies a potent locus associated with human opioid sensitivity

10.1038/mp.2012.164 rs2952768(C) was associated with more analgesic requirements ... exhibited less vulnerability to severe methamphetamine or alcohol dependence, fewer eating disorders, and a lower ‘Reward Dependence’ score on a personality questionnaire. The (C;C) genotype was significantly associated with the elevated expression of a neighboring gene, CREB1. SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics such as morphine and fentanyl and liability to severe substance dependence. These findings may provide valuable information for the personalized treatment of pain and drug dependence.

Other related opioids include buprenorphine, meperidine and pentazocine.

GWAS snp
PMID	[PMID 23183491 ]
Trait	Opioid sensitivity
Title	Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
Risk Allele	C
P-val	8E-7
Odds Ratio	.29 unit increase

ClinVar
Risk	Rs2952768(C;C)
Alt	Rs2952768(C;C)
Reference	Rs2952768(T;T)
Significance	Drug-response
Disease	meperidine response - Dosage pentazocine response - Dosage Morphine response - Dosage buprenorphine response - Dosage Fentanyl response - Dosage Opioids response - Dosage
Variation	info
Gene
CLNDBN	meperidine response - Dosage pentazocine response - Dosage morphine response - Dosage buprenorphine response - Dosage fentanyl response - Dosage opioids response - Dosage
Reversed	0
HGVS	NC_000002.11:g.208494234T>C
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000211200.1, RCV000211227.1, RCV000211287.1, RCV000211288.1, RCV000211383.1, RCV000211411.1,