rs3751812

plus

Geno	Mag	Summary
(G;G)		normal
(G;T)		None
(T;T)		increased risk of obesity

Reference

GRCh38 38.1/141

Chromosome

16

Position

53784548

Gene

FTO

is a	snp
is	mentioned by
dbSNP	rs3751812
dbSNP (classic)	rs3751812
ClinGen	rs3751812
ebi	rs3751812
HLI	rs3751812
Exac	rs3751812
Gnomad	rs3751812
Varsome	rs3751812
LitVar	rs3751812
Map	rs3751812
PheGenI	rs3751812
Biobank	rs3751812
1000 genomes	rs3751812
hgdp	rs3751812
ensembl	rs3751812
geneview	rs3751812
scholar	rs3751812
google	rs3751812
pharmgkb	rs3751812
gwascentral	rs3751812
openSNP	rs3751812
23andMe	rs3751812
SNPshot	rs3751812
SNPdbe	rs3751812
MSV3d	rs3751812
GWAS Ctlg	rs3751812

GMAF

0.242

Max Magnitude

0

?

(G;G) (G;T) (T;T)

28

Within the FTO gene, many SNPs appear to be co-inherited. The SNP showing the strongest association with body weight (i.e. body mass index, BMI) is not rs3751812, although this SNP is one of the co-inherited SNPs in the FTO gene region. For more information, refer to the FTO gene or the most studied FTO SNPs, rs9930506 or rs9939609. [PMID 17658951 ]

23andMe considers rs3751812(T) equivalent to the rs9939609(A)

[PMID 18335027 ] implicated for african americans

[PMID 19322589 ] Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study

[PMID 20430937 ] Fine-mapping of the association with obesity at the FTO locus in African-derived populations

[PMID 21443588] Association between the FTO gene and overweight in Japanese children and adolescents

[PMID 18379722 ] Variations in the FTO gene are associated with severe obesity in the Japanese.

[PMID 18647953 ] Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test.

[PMID 19060910 ] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

[PMID 19074959 ] ATOM: a powerful gene-based association test by combining optimally weighted markers.

[PMID 19265514 ] FTO gene variation and measures of body mass in an African population.

[PMID 19478790 ] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 20381893 ] The genetics of obesity: FTO leads the way.

[PMID 20404173 ] A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly.

[PMID 20442772 ] Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.

[PMID 20502638 ] Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study.

[PMID 20694148 ] A genome-wide association study of the metabolic syndrome in Indian Asian men.

[PMID 21102551 ] Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort.

[PMID 23628854 ] FTO predicts weight regain in the Look AHEAD clinical trial

[PMID 23933215] Body Mass Index, but not FTO genotype or Major Depressive Disorder, influences brain structure

[PMID 23408508 ] Obesity-susceptibility loci and the tails of the pediatric BMI distribution

[PMID 21799482 ] Common genetic variants and central adiposity among Asian-Indians.

[PMID 24911064 ] Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents

[PMID 26726774 ] Gender-Dependent Association of FTO Polymorphisms with Body Mass Index in Mexicans.

[PMID 30822753] Effects of fat mass and obesity-associated (FTO) gene polymorphisms on binge eating in women with binge-eating disorder: The moderating influence of attachment style.

[PMID 31075924 ] Physical Activity Might Reduce the Adverse Impacts of the FTO Gene Variant rs3751812 on the Body Mass Index of Adults in Taiwan.

[PMID 32109558] Implication of Genetic Variants in Overweight and Obesity susceptibility among the Young Arab Population of the United Arab Emirates.