rs3804100
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | somwhat increased risk for type-1 diabetes and allergic asthma | |
| (C;T) | somewhat increased risk for type-1 diabetes and allergic asthma | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 153704257 |
| Gene | TLR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3804100 |
| dbSNP (classic) | rs3804100 |
| ClinGen | rs3804100 |
| ebi | rs3804100 |
| HLI | rs3804100 |
| Exac | rs3804100 |
| Gnomad | rs3804100 |
| Varsome | rs3804100 |
| LitVar | rs3804100 |
| Map | rs3804100 |
| PheGenI | rs3804100 |
| Biobank | rs3804100 |
| 1000 genomes | rs3804100 |
| hgdp | rs3804100 |
| ensembl | rs3804100 |
| geneview | rs3804100 |
| scholar | rs3804100 |
| rs3804100 | |
| pharmgkb | rs3804100 |
| gwascentral | rs3804100 |
| openSNP | rs3804100 |
| 23andMe | rs3804100 |
| SNPshot | rs3804100 |
| SNPdbe | rs3804100 |
| MSV3d | rs3804100 |
| GWAS Ctlg | rs3804100 |
| GMAF | 0.1157 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs3804100, also known as 1350T/C, is a SNP in the toll-like receptor 2 TLR2 gene.
A study of 700 T1D children, 357 nuclear families with T1D children and 796 children from the 'Environment and Childhood Asthma' study concluded that both type-1 diabetes and allergic asthma were significantly associated with the rs3804100(T) allele.[PMID 19148143]
[PMID 22235236
] Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese
[PMID 22309608] The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility
[PMID 18325643] Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results.
[PMID 18396467] Genetic variation and haplotype structures of innate immunity genes in eastern India.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 19029192] A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19543401] Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
[PMID 20057905] Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma.
[PMID 20113509] Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.
[PMID 21424379] The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity.
[PMID 21437199] Toll-like receptor 2 (TLR2) gene polymorphisms are not associated with sarcoidosis in the Japanese population.
[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
[PMID 21887520] Association of toll-like receptor 2 polymorphisms with National Institute of Health Stroke Scale scores of ischemic stroke patients.
[PMID 23484049] Genetic Polymorphisms in Toll-Like Receptors among Pediatric Patients with Renal Parenchymal Infections of Different Clinical Severities
[PMID 23166414] Association of Toll-like receptor 2 polymorphisms with papillary thyroid cancer and clinicopathologic features in a Korean population
[PMID 23906542] Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease
[PMID 25928077] Screening toll-like receptor markers to predict latent tuberculosis infection and subsequent tuberculosis disease in a Chinese population
[PMID 28490891] No genetic relationship between TLR2 rs4696480, rs3804100, and rs3804099 gene polymorphisms and female breast cancer in Saudi populations.
[PMID 28703296] Correlation between TLR2, TLR3, TLR4, and TLR9 polymorphisms and susceptibility to and prognosis of severe hepatitis among the newborns.
[PMID 29348888] The association analysis of TLR2 and TLR4 gene with tuberculosis in the Tibetan Chinese population.
[PMID 29486365] Importance of common TLR2 genetic variants on clinical phenotypes and risk in tuberculosis disease in a Western Chinese population.
[PMID 30532554] Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian population.
