rs3813929
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | possible weight gain if taking olanzapine |
| (C;T) | normal | |
| (T;T) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | X |
| Position | 114584047 |
| Gene | HTR2C |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3813929 |
| dbSNP (classic) | rs3813929 |
| ClinGen | rs3813929 |
| ebi | rs3813929 |
| HLI | rs3813929 |
| Exac | rs3813929 |
| Gnomad | rs3813929 |
| Varsome | rs3813929 |
| LitVar | rs3813929 |
| Map | rs3813929 |
| PheGenI | rs3813929 |
| Biobank | rs3813929 |
| 1000 genomes | rs3813929 |
| hgdp | rs3813929 |
| ensembl | rs3813929 |
| geneview | rs3813929 |
| scholar | rs3813929 |
| rs3813929 | |
| pharmgkb | rs3813929 |
| gwascentral | rs3813929 |
| openSNP | rs3813929 |
| 23andMe | rs3813929 |
| SNPshot | rs3813929 |
| SNPdbe | rs3813929 |
| MSV3d | rs3813929 |
| GWAS Ctlg | rs3813929 |
| GMAF | 0.1167 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs3813929, also known as -759C/T, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene.
A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (T) allele of this SNP; zero patients (of 28) with a rs3813929(T) allele had a body mass index increase of >=10% (p=0.002), whereas (C;C) homozygotes did. This effect may also involve nearby SNP rs518147.[PMID 19434072]
[PMID 20065966] T allele showed borderline significant association with higher BMI and incidence of lifetime major depressive disorder among 4978 persons from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, however, only the association with BMI remained borderline significant within the full EPIC-Norfolk cohort (20,981 persons)
[PMID 19416518
] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
[PMID 19690620] Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes
[PMID 20092861] Further exploration of the possible influence of polymorphisms in HTR2C and 5HTT on body weight
[PMID 20562674] Association between LEP and LEPR gene polymorphisms and dyslipidemia in patients using atypical antipsychotic medication
[PMID 20680028] Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study
[PMID 20504252] Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample
[PMID 21510767] Polymorphisms of the LEP-, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting
[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.
[PMID 17291373] Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis.
[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 18802918] Focus on HTR2C: A possible suggestion for genetic studies of complex disorders.
[PMID 19142101] HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.
[PMID 19359258] Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
[PMID 20060656] Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.
[PMID 21162693] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
[PMID 21391883] Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.
[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy
[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
| ClinVar | |
|---|---|
| Risk | Rs3813929(T;T) |
| Alt | Rs3813929(T;T) |
| Reference | Rs3813929(C;C) |
| Significance | Drug-response |
| Disease | olanzapine response - Toxicity/ADR antipsychotics response - Toxicity/ADR |
| Variation | info |
| Gene | HTR2C |
| CLNDBN | olanzapine response - Toxicity/ADR antipsychotics response - Toxicity/ADR |
| Reversed | 0 |
| HGVS | NC_000023.10:g.113818520C>T |
| CLNSRC | PharmGKB Clinical Annotation |
| CLNACC | RCV000211364.1, RCV000417155.1, |
[PMID 30074224] Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.
