rs518147
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | less weight gain if taking olanzapine | |
| (C;G) | normal | |
| (G;G) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | X |
| Position | 114584109 |
| Gene | HTR2C |
| is a | snp |
| is | mentioned by |
| dbSNP | rs518147 |
| dbSNP (classic) | rs518147 |
| ClinGen | rs518147 |
| ebi | rs518147 |
| HLI | rs518147 |
| Exac | rs518147 |
| Gnomad | rs518147 |
| Varsome | rs518147 |
| LitVar | rs518147 |
| Map | rs518147 |
| PheGenI | rs518147 |
| Biobank | rs518147 |
| 1000 genomes | rs518147 |
| hgdp | rs518147 |
| ensembl | rs518147 |
| geneview | rs518147 |
| scholar | rs518147 |
| rs518147 | |
| pharmgkb | rs518147 |
| gwascentral | rs518147 |
| openSNP | rs518147 |
| 23andMe | rs518147 |
| SNPshot | rs518147 |
| SNPdbe | rs518147 |
| MSV3d | rs518147 |
| GWAS Ctlg | rs518147 |
| GMAF | 0.2926 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs518147, also known as -697G/C, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene.
A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (C) allele of this SNP; fewer patients (of 28) with a rs518147(C) allele had a body mass index increase of >=10% (p=0.0006), whereas (G;G) homozygotes did. This effect may also involve nearby SNP rs3813929.[PMID 19434072]
[PMID 19416518
] Investigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
[PMID 17016522] The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.
[PMID 17632216] The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.
[PMID 18081710] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
[PMID 19142101] HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.
[PMID 20060656] Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.
[PMID 20415561] HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients.
[PMID 21391883] Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.
[PMID 22914617] Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome.
[PMID 30074224] Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis.
