Olanzapine is the chemical name for medications marked under the trade name Zyprexa, or when combined with fluoxetine, Symbyax.
Olanzapine is an atypical antipsychotic, approved by the FDA for the treatment of schizophrenia, depressive episodes associated with bipolar disorder (as part of the Symbyax formulation, and acute manic episodes and maintenance treatment in bipolar disorder.[Wikipedia]
Certain SNPs have been reported to be associated with altered response to olanzapine, including:
- rs6280, correlated to better response among schizophrenia patients
- rs7412, rs5092, and rs4765623: correlated with weight profile changes in patients taking olanzapine
- rs3813929 and rs518147, also correlated to weight gain (or lack thereof) in patients taking olanzapine
Gut microflora and Olanzapine in mice http://www.nature.com/tp/journal/v3/n10/full/tp201383a.html