| Geno
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Mag
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Summary
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| (A;A)
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more likely to gain weight if taking olanzapine
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| (A;G)
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less likely to gain weight if taking olanzapine
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| (G;G)
|
|
less likely to gain weight if taking olanzapine
|
rs5092 is a SNP in the apolipoprotein A4 APOA4 gene.
In a study of 67 mostly Caucasian patients prescribed the atypical antipsychotic olanzapine, carriers of a rs5092(G) allele were less likely to gain significant weight compared to rs5092(A;A) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs4765623 and rs7412, were also significantly associated with weight profiles in these patients.[PMID 17199131]
[PMID 19592705
] Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
[PMID 18254975] Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.
[PMID 19057464] Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
] Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men
