rs4986910

minus

Geno	Mag	Summary
(C;C)		CYP3A4*3 homozygote
(C;T)		carrier of one CYP3A4*3 allele
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

7

Position

99760901

Gene

CYP3A4

is a	snp
is	mentioned by
dbSNP	rs4986910
dbSNP (classic)	rs4986910
ClinGen	rs4986910
ebi	rs4986910
HLI	rs4986910
Exac	rs4986910
Gnomad	rs4986910
Varsome	rs4986910
LitVar	rs4986910
Map	rs4986910
PheGenI	rs4986910
Biobank	rs4986910
1000 genomes	rs4986910
hgdp	rs4986910
ensembl	rs4986910
geneview	rs4986910
scholar	rs4986910
google	rs4986910
pharmgkb	rs4986910
gwascentral	rs4986910
openSNP	rs4986910
23andMe	rs4986910
SNPshot	rs4986910
SNPdbe	rs4986910
MSV3d	rs4986910
GWAS Ctlg	rs4986910

GMAF

0.003214

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs4986910, also known as 1334T>C, 23171T>C or M445T, is a SNP in the CYP3A4 gene.

The rs4986910(C) allele defines the CYP3A4*3 variant.

[PMID 19214745 ] Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists

[PMID 17615053 ] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

[PMID 19076156 ] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.