CYP3A4
| is a | gene |
| is | mentioned by |
| Full name | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Other names | CYP3A |
| EntrezGene | 1576 |
| PheGenI | 1576 |
| VariationViewer | 1576 |
| ClinVar | CYP3A4 |
| GeneCards | CYP3A4 |
| dbSNP | 1576 |
| Diseases | CYP3A4 |
| SADR | 1576 |
| HugeNav | 1576 |
| CYPANC | cyp3a4 |
| wikipedia | CYP3A4 |
| CYP3A4 | |
| gopubmed | CYP3A4 |
| EVS | CYP3A4 |
| HEFalMp | CYP3A4 |
| MyGene2 | CYP3A4 |
| 23andMe | CYP3A4 |
| UniProt | P08684 |
| Ensembl | ENSG00000160868 |
| OMIM | 124010 |
| # SNPs | 31 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1041988 | 0 | 99,760,943 | |
| rs11773597 | 0 | 99,784,828 | |
| rs12721627 | 0 | 99,768,470 | |
| rs12721629 | 2.5 | 99,762,177 | |
| rs12721634 | 0 | 99,784,038 | |
| rs2242480 | 0 | 99,763,843 | |
| rs2246709 | 0 | 99,768,096 | |
| rs2687116 | 0 | 99,768,320 | |
| rs2740574 | 2 | 99,784,473 | |
| rs28371759 | 0 | 99,764,003 | |
| rs3091339 | 0 | 99,772,622 | |
| rs3208361 | 0 | 99,768,447 | |
| rs3208363 | 0 | 99,767,175 | |
| rs35599367 | 0 | 99,768,693 | |
| rs45614732 | 0 | 99,762,177 | |
| rs4646437 | 0 | 99,767,460 | |
| rs4646438 | 0 | 99,766,411 | |
| rs4646440 | 0 | 99,763,247 | |
| rs4986907 | 0 | 99,769,804 | |
| rs4986908 | 0 | 99,769,769 | |
| rs4986909 | 0 | 99,762,047 | |
| rs4986910 | 0 | 99,760,901 | |
| rs4986913 | 0 | 99,760,836 | |
| rs4987161 | 0 | 99,768,458 | |
| rs55785340 | 0 | 99,768,360 | |
| rs55901263 | 0 | 99,768,371 | |
| rs55951658 | 0 | 99,770,202 | |
| rs56324128 | 0 | 99,778,079 | |
| rs67666821 | 5 | 99,758,183 | CYP3A4 variant affecting acetaminophen, codeine and other medicines |
| rs67784355 | 0 | 99,762,206 | |
| rs72552799 | 0 | 99,770,165 |
The wikipedia article on CYP3A4 is a good resource to learn about the many drugs and chemicals that the protein encoded by this gene metabolizes. CYP3A4 is the most abundant detoxifying enzyme in the liver, and is responsible for helping to break down perhaps 60% of all known drugs. It also has an important role in the breakdown of testosterone.
One of the best known consequences of interfering with CYP3A4 function comes from the consequences of drinking grapefruit juice while taking medications metabolized by CYP3A4. Grapefruit juice inhibits the action of CYP3A4, which results in a higher concentration of many drugs within the body. This can have both positive and negative medical consequences. Wiki article OMIM
CYP3A4 is quite strongly conserved, and although some variants have been described, the in vivo activities of most corresponding proteins have not been shown to be different from wild-type CYP3A4*1. One variant that is actually nonfunctional, CYP3A4*20, is exceedingly rare (rs67666821).[PMID 16580902]
CYP3A4 is also located quite close to CYP3A5, and so some effects thought to be due to a CYP3A4 allele may actually due to a linked CYP3A5 allele. [1]
In African American males, CYP3A4 variation rs2740574 is associated with a ~10 fold higher risk of prostate cancer being of an aggressive form. [PMID 16414488]
CYP3A4 alleles and variants include the following:
