|(A;A)||2||Faster aging. Increased risk for Dementia. Less good cholesterol.|
|(A;G)||2||Lower risk of dementia and Alzheimer's disease. Higher good cholesterol.|
|(G;G)||2.1||Longer lifespan, 0.28x lower risk of dementia, 0.31x lower risk of Alzheimer's.|
New research also indicates that G homozygotes have an average of 70% less risk of dementia and Alzheimer's disease. The study also found that heterozygotes have a lower risk of dementia and Alzheimer's disease but more study is needed to determine the risk reduction for heterozygotes. See Association of a Functional Polymorphism in the Cholesteryl Ester Transfer Protein (CETP) Gene With Memory Decline and Incidence of Dementia and CETP Variant Linked to Slower Cognitive Decline and Reduced Dementia Risk [PMID 20068209].
[PMID 20855565] Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease
[PMID 22122979] The CETP I405V polymorphism is associated with an increased risk of Alzheimer's disease
[PMID 22403620] Cholesteryl Ester Transfer Protein (CETP) Polymorphisms Affect mRNA Splicing, HDL Levels, and Sex-Dependent Cardiovascular Risk
|Disease||High density lipoprotein cholesterol level quantitative trait locus 10 Hyperalphalipoproteinemia|
|CLNDBN||High density lipoprotein cholesterol level quantitative trait locus 10 Hyperalphalipoproteinemia|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
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