rs6449213

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(C;C)	2	~4x higher risk for hyperuracemia
(C;T)		~2x higher risk for hyperuracemia
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

4

Position

9992591

Gene	LOC105374476, SLC2A9

is a	snp
is	mentioned by
dbSNP	rs6449213
dbSNP (classic)	rs6449213
ClinGen	rs6449213
ebi	rs6449213
HLI	rs6449213
Exac	rs6449213
Gnomad	rs6449213
Varsome	rs6449213
LitVar	rs6449213
Map	rs6449213
PheGenI	rs6449213
Biobank	rs6449213
1000 genomes	rs6449213
hgdp	rs6449213
ensembl	rs6449213
geneview	rs6449213
scholar	rs6449213
google	rs6449213
pharmgkb	rs6449213
gwascentral	rs6449213
openSNP	rs6449213
23andMe	rs6449213
SNPshot	rs6449213
SNPdbe	rs6449213
MSV3d	rs6449213
GWAS Ctlg	rs6449213

GMAF

0.1299

Max Magnitude

2

?	(C;C) (C;T) (T;T)	28

This is basically a surrogate for rs7442295, and thus associated with higher serum urate levels.

OMIM	612076
Desc	HYPOURICEMIA, RENAL, 2; RHUC2
Variant
Related	also

OMIM	606142
Desc	SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
Variant
Related	also

[PMID 20589538] Variation in the Uric Acid Transporter Gene SLC2A9 and Its Association with AAO of Parkinson's Disease

OMIM	606142
Desc
Variant	0002
Related	also

[PMID 18179892] Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

[PMID 18398472] Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.

[PMID 18487473] Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI.

[PMID 18606621] SLC2A9--a fructose transporter identified as a novel uric acid transporter.

[PMID 18834626] Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

[PMID 19260141] Genome-wide association study of biochemical traits in Korcula Island, Croatia.

[PMID 20053405] Sex and age interaction with genetic association of atherogenic uric acid concentrations.

[PMID 20162742] Predictive value of 8 genetic loci for serum uric acid concentration.

[PMID 20162743] Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.

[PMID 20162744] Interactions between genetic variants in glucose transporter type 9 (SLC2A9) and dietary habits in serum uric acid regulation.

[PMID 20162745] Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.

[PMID 20348110] Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome.

[PMID 21294900] A genome-wide association study of serum uric acid in African Americans.

GWAS snp
PMID	[PMID 23703922]
Trait	Uric acid levels
Title	A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.
Risk Allele
P-val	3E-12
Odds Ratio	NR NR

[PMID 26552468] Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population

ClinVar
Risk	Rs6449213(T;T)
Alt	Rs6449213(T;T)
Reference	Rs6449213(C;C)
Significance	Other
Disease	Uric acid concentration
Variation	info
Gene	SLC2A9
CLNDBN	Uric acid concentration, serum, quantitative trait locus 2
Reversed	0
HGVS	NC_000004.11:g.9994215C>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000004857.2,