rs713041
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.3x increased risk of death if diagnosed with breast cancer | |
| (T;T) | >1.3x increased risk of death if diagnosed with breast cancer |
| Reference | GRCh38 38.1/141 |
| Chromosome | 19 |
| Position | 1106616 |
| Gene | GPX4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs713041 |
| dbSNP (classic) | rs713041 |
| ClinGen | rs713041 |
| ebi | rs713041 |
| HLI | rs713041 |
| Exac | rs713041 |
| Gnomad | rs713041 |
| Varsome | rs713041 |
| LitVar | rs713041 |
| Map | rs713041 |
| PheGenI | rs713041 |
| Biobank | rs713041 |
| 1000 genomes | rs713041 |
| hgdp | rs713041 |
| ensembl | rs713041 |
| geneview | rs713041 |
| scholar | rs713041 |
| rs713041 | |
| pharmgkb | rs713041 |
| gwascentral | rs713041 |
| openSNP | rs713041 |
| 23andMe | rs713041 |
| SNPshot | rs713041 |
| SNPdbe | rs713041 |
| MSV3d | rs713041 |
| GWAS Ctlg | rs713041 |
| GMAF | 0.4036 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
Two SNPs associated with the antioxidant GPX4 gene, rs713041 and rs757229, are both somewhat correlated (r2=0.61) and are associated with all-cause mortality in breast cancer.
The rs713041(T) allele is associated with an increased risk of death following breast cancer diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).[PMID 17634480]
[PMID 20378690] Genetic variants in selenoprotein genes increase risk of colorectal cancer
[PMID 21733339] SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease
[PMID 20003265
] Extent of differential allelic expression of candidate breast cancer genes is similar in blood and breast.
[PMID 20852007] Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.
[PMID 21459128] A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells.
[PMID 22139612] Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand.
[PMID 24499375] Association of Oxidative Stress Related Genes with Idiopathic Recurrent Miscarriage
[PMID 26081749] Antioxidant-related gene polymorphisms associated with the cardio-ankle vascular index in young Russians
[PMID 26446998] Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1
[PMID 29331597] Variation of genes involved in oxidative and nitrosative stresses in depression.
[PMID 32185238] Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.
