rs717620

minus

Geno	Mag	Summary
(G;G)	0	common in clinvar

Make rs717620(A;A)

Make rs717620(A;G)

Reference

GRCh38.p2 38.2/146

Chromosome

10

Position

99782821

Gene

ABCC2

is a	snp
is	mentioned by
dbSNP	rs717620
dbSNP (classic)	rs717620
ClinGen	rs717620
ebi	rs717620
HLI	rs717620
Exac	rs717620
Gnomad	rs717620
Varsome	rs717620
LitVar	rs717620
Map	rs717620
PheGenI	rs717620
Biobank	rs717620
1000 genomes	rs717620
hgdp	rs717620
ensembl	rs717620
geneview	rs717620
scholar	rs717620
google	rs717620
pharmgkb	rs717620
gwascentral	rs717620
openSNP	rs717620
23andMe	rs717620
SNPshot	rs717620
SNPdbe	rs717620
MSV3d	rs717620
GWAS Ctlg	rs717620

GMAF

0.1763

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

[PMID 21451505 ] Effect of ABCC2 (MRP2) Transport Function on Erythromycin Metabolism

[PMID 22630058 ] ABCC2 Polymorphisms and Haplotype are Associated with Drug Resistance in Chinese Epileptic Patients

[PMID 17997497] Association of the multidrug-resistance-associated protein gene (ABCC2) variants with intrahepatic cholestasis of pregnancy.

[PMID 18926681] Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease.

[PMID 19568750 ] MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer.

[PMID 20061166] Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.

[PMID 20139798] ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.

[PMID 22318656 ] Interindividual variability in hepatic expression of the multidrug resistance-associated protein 2 (MRP2/ABCC2): quantification by liquid chromatography/tandem mass spectrometry.

[PMID 22473764] A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis.

[PMID 23506516] A systematic review and meta-analysis of the role of ABCC2 variants on drug response in patients with epilepsy

[PMID 22868256 ] A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen.

[PMID 23069858] Impact of ABCC2 polymorphisms on high-dose methotrexate pharmacokinetics in patients with lymphoid malignancy.

[PMID 24782687 ] Multi-institutional Study of Outcomes After Pediatric Heart Transplantation: Candidate Gene Polymorphism Analysis of ABCC2

[PMID 25007187] Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia

[PMID 26107220] Quantitative Assessment of the Association between ABC Polymorphisms and Osteosarcoma Response: a Meta-analysis

[PMID 26189305] ABCB1, ABCC2, SCN1A, SCN2A, GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population

[PMID 26807589 ] A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection.

[PMID 27566582 ] Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma.

ClinVar
Risk	rs717620(A;A)
Alt	rs717620(A;A)
Reference	Rs717620(G;G)
Significance	Probable-non-pathogenic
Disease	Dubin-Johnson syndrome
Variation	info
Gene	ABCC2
CLNDBN	Dubin-Johnson syndrome
Reversed	1
HGVS	NC_000010.10:g.101542578C>T
CLNSRC
CLNACC	RCV000404794.1,

[PMID 30024814] Association of ABCC2 polymorphism and gender with high-density lipoprotein cholesterol response to simvastatin.

[PMID 31391850 ] Role of Four ABC Transporter Genes in Pharmacogenetic Susceptibility to Breast Cancer in Jordanian Patients.