rs744373
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | 1.28x risk of Alzheimer's |
| (C;T) | 2 | 1.13x risk of Alzheimer's |
| (T;T) | 1 | Normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 127137039 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs744373 |
| dbSNP (classic) | rs744373 |
| ClinGen | rs744373 |
| ebi | rs744373 |
| HLI | rs744373 |
| Exac | rs744373 |
| Gnomad | rs744373 |
| Varsome | rs744373 |
| LitVar | rs744373 |
| Map | rs744373 |
| PheGenI | rs744373 |
| Biobank | rs744373 |
| 1000 genomes | rs744373 |
| hgdp | rs744373 |
| ensembl | rs744373 |
| geneview | rs744373 |
| scholar | rs744373 |
| rs744373 | |
| pharmgkb | rs744373 |
| gwascentral | rs744373 |
| openSNP | rs744373 |
| 23andMe | rs744373 |
| SNPshot | rs744373 |
| SNPdbe | rs744373 |
| MSV3d | rs744373 |
| GWAS Ctlg | rs744373 |
| GMAF | 0.3714 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs6733839 and rs744373 are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.
[PMID 20460622
] Genome-wide analysis of genetic loci associated with Alzheimer's disease
[PMID 21321396] Replication of BIN1 Association with Alzheimer's Disease and Evaluation of Genetic Interactions
| GWAS snp | |
|---|---|
| PMID | [PMID 21390209]
|
| Trait | |
| Title | Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease |
| Risk Allele | |
| P-val | 1E-10 |
| Odds Ratio | 1.1900 [NR] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21460840]
|
| Trait | |
| Title | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease |
| Risk Allele | |
| P-val | 3E-14 |
| Odds Ratio | 1.1700 [1.12-1.21] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21627779]
|
| Trait | |
| Title | The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. |
| Risk Allele | |
| P-val | 2E-9 |
| Odds Ratio | 1.1800 [NR] |
[PMID 19734902] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
[PMID 21220176] Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.
[PMID 21347408] Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
[PMID 21379329] Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
[PMID 23570733] BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population
[PMID 24260488] Epistatic Genetic Effects among Alzheimer's Candidate Genes
[PMID 22005930] Genome-wide association study of Alzheimer's disease with psychotic symptoms.
[PMID 22430674] Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
[PMID 23180304] Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease.
[PMID 26680604] Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China.
[PMID 28316001] Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance.
[PMID 30992433] The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
[PMID 33521641] BIN1 rs744373 SNP and COVID-19 mortality.
