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From SNPedia

Geno Mag Summary
(C;C) 0.2 mixed evidence of increased obesity risk, may suppress excercise effects in men
(C;G) ?
(G;G) 0 common
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs7566605
1000 genomesrs7566605
23andMe allrs7566605
GWAS Ctlgrs7566605
Max Magnitude0.2
? (C;C) (C;G) (G;G) 28

rs7566605 was initially reported as being associated in at least 4 independent populations as being associated with obesity however replications are inconsistent, and a recent (2009) large meta-analysis comprising 34 studies (and over 70,000 subjects) has concluded that there is no evidence for overall association of the rs7566605 polymorphism with obesity.[PMID 19851442OA-icon.png] See also: [PMID 16614226] Poster

At least one population has since been reported in which this association was not seen. [PMID 17218508] Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of obesity, except that among physically inactive subjects, (C)-allele carriers tended to have a higher body mass index (by O.5 kg/m2) than (G)-allele carriers.[PMID 18682847OA-icon.png]

On the other hand, a report has also been published indicating that obese children who are rs7566605(C;C) homozygotes find it harder to lose weight in clinical intervention programs than (C;G) heterozygotes or (G;G) homozygotes, which supports the association of SNP rs7566605 with obesity. [PMID 18003761]

[PMID 18570692] associated with the prevalence of hypercholesterolemia, but not with obesity, in Japanese American women. In Japanese American women, rs7566605(C;C) individuals had a 0.43-fold decreased risk (CI: 0.24 - 0.80) for hypercholesterolemia compared with the (G;G) homozygotes after adjustment for age and other factors. No significant differences in BMI, waist girth and percentage body fat according to the genotype in each of the four groups, which was divided by population and sex. The rs7566605(C;C) genotype is suggested to be a protective genetic factor against the progression of hypercholesterolemia on a high-fat diet, especially in Japanese female subjects.

[PMID 18839134OA-icon.png] rs9939609 and rs7566605 linked to obesity

[PMID 19105843OA-icon.png] underlies variation in subcutaneous adiposity in young adult women and suppresses the positive effects of resistance training on men.

[PMID 19197259] does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors

[PMID 19197262] rs7566605 is not associated with obesity-related traits and lipids in the ~2,00 person European Youth Heart Study.

[PMID 19197259] rs7566605 near the INSIG2 gene does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors in a study of ~7,000 German adults.

[PMID 19263810] Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents

[PMID 19360016OA-icon.png] INSIG2 SNPs Associated With Obesity and Glucose Homeostasis Traits in Hispanics: The IRAS Family Study

[PMID 19399648] Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants

[PMID 19523229OA-icon.png] The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts


[PMID 19772594OA-icon.png] Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations

[PMID 20028541OA-icon.png] A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans

[PMID 20045156OA-icon.png] Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age

[PMID 20373477] Association study of polymorphisms in Insulin Induced Gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients

[PMID 20858904] Fine Mapping of the INSIG2 Gene Identifies a Variant Associated with Low-Density Lipoprotein Cholesterol and Total ApoB Levels

[PMID 20920244OA-icon.png] Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent

[PMID 20955599OA-icon.png] The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk

[PMID 20504252] Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample

[PMID 17024366] Lack of association between rs7566605 and obesity in a Chinese population.

[PMID 17137505OA-icon.png] INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.

[PMID 17389899] Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia?

[PMID 17465681OA-icon.png] The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.

[PMID 17471297] INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.

[PMID 17489846] The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.

[PMID 17903300OA-icon.png] Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project.

[PMID 18070740] No association between rs7566605 variant and being overweight in Japanese.

[PMID 18096054OA-icon.png] Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.

[PMID 18162505] Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento.

[PMID 18223638] No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.

[PMID 18239574] INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.

[PMID 18270535] Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.

[PMID 18304332OA-icon.png] No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.

[PMID 18325910OA-icon.png] Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.

[PMID 18387595OA-icon.png] On the replication of genetic associations: timing can be everything!

[PMID 18426866OA-icon.png] Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.

[PMID 18514965] A common polymorphism is associated with body mass index in Uyghur population.

[PMID 18615239OA-icon.png] INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.

[PMID 19079261OA-icon.png] Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

[PMID 19107338] Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan.

[PMID 19224890] Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention.

[PMID 19245693OA-icon.png] Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.

[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 19593725OA-icon.png] Association of maternally inherited GNAS alleles with African-American male birth weight.

[PMID 19965593OA-icon.png] INSIG1 influences obesity-related hypertriglyceridemia in humans.

[PMID 20092643OA-icon.png] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.

[PMID 20354568OA-icon.png] INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.

[PMID 20645959] An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 21233811] Multilocus analyses of seven candidate genes suggest interacting pathways for obesity-related traits in Brazilian populations.

[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

Obesity: Preliminary Research

[PMID 23941145] Association between intramuscular fat in the arm following arm training and INSIG2

[PMID 24167462OA-icon.png] FTO and INSIG2 Genotyping Combined with Metabolic and Anthropometric Phenotyping of Morbidly Obese Patients

[PMID 22038464] Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.

[PMID 22968099OA-icon.png] INSIG2 variants, dietary patterns and metabolic risk in Samoa.

[PMID 23318717] Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.

[PMID 30858138] Decision tree learning to predict overweight/obesity based on body mass index and gene polymporphisms.

[PMID 31144980] INSIG2 gene polymorphism is associated with higher blood pressure and triglyceride levels in Brazilian obese subjects.