HLA-B
| is a | gene |
| is | mentioned by |
| Full name | major histocompatibility complex, class I, B |
| EntrezGene | 3106 |
| PheGenI | 3106 |
| VariationViewer | 3106 |
| ClinVar | HLA-B |
| GeneCards | HLA-B |
| dbSNP | 3106 |
| Diseases | HLA-B |
| SADR | 3106 |
| HugeNav | 3106 |
| wikipedia | HLA-B |
| HLA-B | |
| gopubmed | HLA-B |
| EVS | HLA-B |
| HEFalMp | HLA-B |
| MyGene2 | HLA-B |
| 23andMe | HLA-B |
| UniProt | P01889 |
| Ensembl | ENSG00000234745 |
| OMIM | 142830 |
| # SNPs | 924 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1049645 | 0 | 31,354,145 | |
| rs1050240 | 0 | 31,355,357 | |
| rs1050341 | 0 | 31,355,560 | |
| rs1050368 | 0 | 31,356,301 | |
| rs1050370 | 0 | 31,356,312 | |
| rs1050379 | 0 | 31,356,377 | |
| rs1050388 | 0 | 31,356,729 | |
| rs1050393 | 0 | 31,356,742 | |
| rs1050458 | 0 | 31,357,148 | |
| rs1050459 | 0 | 31,357,144 | |
| rs1050462 | 0 | 31,357,134 | |
| rs1050486 | 0 | 31,356,925 | |
| rs1050502 | 0 | 31,356,890 | |
| rs1050517 | 0 | 31,356,866 | |
| rs1050518 | 0 | 31,356,864 | |
| rs1050529 | 0 | 31,356,838 | |
| rs1050538 | 0 | 31,356,822 | |
| rs1050543 | 0 | 31,356,818 | |
| rs1050556 | 0 | 31,356,809 | |
| rs1050564 | 0 | 31,356,785 | |
| rs1050570 | 0 | 31,356,772 | |
| rs1050628 | 0 | 31,356,375 | |
| rs1050642 | 0 | 31,356,351 | |
| rs1050654 | 0 | 31,356,323 | |
| rs1050683 | 0 | 31,356,242 | |
| rs1050692 | 0 | 31,356,214 | |
| rs1050696 | 0 | 31,356,203 | |
| rs1050723 | 0 | 31,355,544 | |
| rs1050747 | 0 | 31,355,519 | |
| rs1050823 | 0 | 31,355,426 | |
| rs1051488 | 0 | 31,355,134 | |
| rs1053726 | 0 | 31,354,270 | |
| rs1054111 | 0 | 31,354,249 | |
| rs1055149 | 0 | 31,354,181 | |
| rs1055348 | 0 | 31,354,171 | |
| rs1055821 | 0 | 31,354,142 | |
| rs1055849 | 0 | 31,354,139 | |
| rs1055890 | 0 | 31,354,138 | |
| rs1058026 | 0 | 31,353,908 | |
| rs1065378 | 0 | 31,356,856 | |
| rs1065386 | 0 | 31,356,770 | |
| rs1065502 | 0 | 31,355,378 | |
| rs1071652 | 0 | 31,356,424 | |
| rs1071816 | 0 | 31,356,759 | |
| rs1071817 | 0 | 31,356,751 | |
| rs1093 | 0 | 31,354,129 | |
| rs111301312 | 0 | 31,354,331 | |
| rs1131112 | 0 | 31,356,407 | |
| rs1131156 | 0 | 31,357,118 | |
| rs1131159 | 0 | 31,357,115 | |
| ... further results | |||
HLA-B is a gene/antigen in the HLA system. There are hundreds of alleles, with many similar variants grouped together, that form subtypes HLA-B*2701 to HLA-B*2763. The genotype is connected with immunity and autoimmune diseases, specifically autoimmune forms of arthritis.
Two commonly tested tag SNPs for HLA-B27 are rs13202464 and rs4349859. Another tag SNP that is sometimes tested is rs3819299.
HLA-B27 (but not HLA-B*27:09) is associated with ankylosing spondylitis, reactive arthritis, psoriasis and psoratic arthritis, inflammatory bowel disease, and acute anterior uveitis; Many individuals that carry the allele have some symptoms (especially uveitis), but most with the allele do not have ankylosing spondylitis.
See HLA-B27 Syndromes.
HLA-B51 is associated with Behçet's disease and other inflammatory joint and skin diseases.
Two associated tag SNPs for HLA-B51 are rs79556279 and rs76546355. [PMID 24821759]
HLA-B*1502, *5701, and *5801 are associated with drug reactions.
HIV: HLA-B27 or HLA-B57 progress slower, HLA-B35 faster.
HLA-B53 protects against malaria and is most common in West Africa.
Tag SNPs for HLA-B antitypes on the 1M Illumina chip[edit]
| HLA | SNP | r2 | HLA_FRQ | SNP_FRQ |
|---|---|---|---|---|
| B*07:04 | rs3104402 | 0.009 | 0.000 | 0.02 |
| B*15:02 | rs2395148 | 0.025 | 0.003 | 0.03 |
| B*15:03 | rs7742033 | 0.054 | 0.005 | 0.02 |
| B*15:04 | rs9391714 | 0.009 | 0.000 | 0.03 |
| B*15:05 | rs6903896 | 0.004 | 0.000 | 0.03 |
| B*15:06 | rs9500864 | 0.008 | 0.000 | 0.02 |
| B*15:07 | rs17493811 | 0.016 | 0.001 | 0.04 |
| B*15:08 | rs9357117 | 0.027 | 0.001 | 0.02 |
| B*15:09 | rs16899178 | 0.007 | 0.000 | 0.05 |
| B*15:10 | rs3093542 | 0.043 | 0.002 | 0.02 |
| B*15:13 | rs9357117 | 0.041 | 0.001 | 0.02 |
| B*15:15 | rs2021783 | 0.018 | 0.000 | 0.01 |
| B*15:16 | rs3218822 | 0.014 | 0.001 | 0.02 |
| B*15:18 | rs16899178 | 0.033 | 0.003 | 0.05 |
| B*15:21 | rs6902544 | 0.069 | 0.001 | 0.01 |
| B*15:24 | rs3895681 | 0.015 | 0.000 | 0.01 |
| B*15:25 | rs2859110 | 0.017 | 0.001 | 0.01 |
| B*15:26 | rs3763288 | 0.021 | 0.002 | 0.09 |
| B*15:27 | rs3817964 | 0.003 | 0.000 | 0.06 |
| B*15:30 | rs9405015 | 0.009 | 0.000 | 0.02 |
| B*18:02 | rs12662077 | 0.010 | 0.001 | 0.05 |
| B*27 | rs13202464 | 0.071 | 0.07 | |
| B*27:03 | rs9366775 | 0.007 | 0.000 | 0.03 |
| B*27:04 | rs3819299 | 0.023 | 0.001 | 0.06 |
| B*27:07 | rs3093671 | 0.021 | 0.001 | 0.03 |
| B*35:02 | rs2073724 | 0.058 | 0.010 | 0.08 |
| B*35:05 | rs2073724 | 0.032 | 0.003 | 0.08 |
| B*35:12 | rs3093561 | 0.086 | 0.001 | 0.01 |
| B*35:14 | rs2517623 | 0.018 | 0.000 | 0.01 |
| B*35:17 | rs3093561 | 0.029 | 0.001 | 0.01 |
| B*35:21 | rs7761890 | 0.009 | 0.000 | 0.02 |
| B*35:43 | rs9366775 | 0.012 | 0.000 | 0.03 |
| B*38:02 | rs2233954 | 0.049 | 0.004 | 0.05 |
| B*39:01 | rs6910087 | 0.060 | 0.010 | 0.16 |
| B*39:02 | rs7761890 | 0.006 | 0.000 | 0.02 |
| B*39:08 | rs4711250 | 0.015 | 0.000 | 0.01 |
| B*39:09 | rs2071288 | 0.011 | 0.001 | 0.01 |
| B*39:10 | rs9469093 | 0.008 | 0.001 | 0.02 |
| B*40:05 | rs16899178 | 0.006 | 0.000 | 0.05 |
| B*40:09 | rs3093561 | 0.014 | 0.000 | 0.01 |
| B*40:10 | rs35759989 | 0.005 | 0.000 | 0.03 |
| B*40:23 | rs2021783 | 0.018 | 0.000 | 0.01 |
| B*42:02 | rs9468942 | 0.047 | 0.001 | 0.01 |
| B*44:04 | rs3130666 | 0.016 | 0.000 | 0.02 |
| B*45:01 | rs2523477 | 0.087 | 0.010 | 0.08 |
| B*48:01 | rs3093668 | 0.052 | 0.003 | 0.02 |
| B*50:02 | rs915653 | 0.010 | 0.000 | 0.02 |
| B*51 | rs79556279 | 0.057 | 0.06 | |
| B*51:02 | rs3093561 | 0.038 | 0.001 | 0.01 |
| B*51:05 | rs3093665 | 0.021 | 0.000 | 0.02 |
| B*51:06 | rs6903896 | 0.017 | 0.001 | 0.03 |
| B*51:08 | rs7747738 | 0.017 | 0.001 | 0.03 |
| B*54:01 | rs3819284 | 0.077 | 0.002 | 0.02 |
| B*56:03 | rs2021783 | 0.018 | 0.000 | 0.01 |
| B*56:04 | rs3819284 | 0.019 | 0.000 | 0.02 |
| B*57 | rs2395029 | 0.057 | 0.05 | |
| B*57:02 | rs9296020 | 0.007 | 0.000 | 0.01 |
| B*57:03 | rs9468559 | 0.007 | 0.001 | 0.02 |
| B*58:02 | rs6902738 | 0.053 | 0.002 | 0.01 |
| B*73:01 | rs2071288 | 0.060 | 0.001 | 0.01 |
| B*78:01 | rs7747738 | 0.017 | 0.001 | 0.03 |
| B*81:01 | rs9263582 | 0.014 | 0.001 | 0.05 |
