rs198358
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | normal | |
| (A;G) | lower blood pressure | |
| (G;G) | lower blood pressure |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 11844019 |
| Gene | NPPA-AS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs198358 |
| dbSNP (classic) | rs198358 |
| ClinGen | rs198358 |
| ebi | rs198358 |
| HLI | rs198358 |
| Exac | rs198358 |
| Gnomad | rs198358 |
| Varsome | rs198358 |
| LitVar | rs198358 |
| Map | rs198358 |
| PheGenI | rs198358 |
| Biobank | rs198358 |
| 1000 genomes | rs198358 |
| hgdp | rs198358 |
| ensembl | rs198358 |
| geneview | rs198358 |
| scholar | rs198358 |
| rs198358 | |
| pharmgkb | rs198358 |
| gwascentral | rs198358 |
| openSNP | rs198358 |
| 23andMe | rs198358 |
| SNPshot | rs198358 |
| SNPdbe | rs198358 |
| MSV3d | rs198358 |
| GWAS Ctlg | rs198358 |
| GMAF | 0.2351 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower blood pressure and hypertension were associated with SNPs rs17376328(A), rs5068, rs198358(C), rs632793(G)
[PMID 19219041
]23andMe blog
[PMID 19326473] Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
[PMID 19439027] Dissecting complex traits: recent advances in hypertension genomics.
[PMID 20031578] Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
[PMID 20407391] Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study.
[PMID 21276798] Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.
[PMID 22504314] Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
[PMID 23315043] Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study
[PMID 30262711] Smoking modifies the effect of two independent SNPs rs5063 and rs198358 of NPPA on central obesity in the Chinese Han population.
[PMID 31341238] Associations among NPPA gene polymorphisms, serum ANP levels, and hypertension in the Chinese Han population.
