rs3750344

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)	0	common in complete genomics

Make rs3750344(A;G)

Make rs3750344(G;G)

Reference

GRCh38 38.1/141

Chromosome

9

Position

98578034

Gene

GABBR2

is a	snp
is	mentioned by
dbSNP	rs3750344
dbSNP (classic)	rs3750344
ClinGen	rs3750344
ebi	rs3750344
HLI	rs3750344
Exac	rs3750344
Gnomad	rs3750344
Varsome	rs3750344
LitVar	rs3750344
Map	rs3750344
PheGenI	rs3750344
Biobank	rs3750344
1000 genomes	rs3750344
hgdp	rs3750344
ensembl	rs3750344
geneview	rs3750344
scholar	rs3750344
google	rs3750344
pharmgkb	rs3750344
gwascentral	rs3750344
openSNP	rs3750344
23andMe	rs3750344
SNPshot	rs3750344
SNPdbe	rs3750344
MSV3d	rs3750344
GWAS Ctlg	rs3750344

GMAF

0.1795

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

[PMID 15759211] Associated with Nicotine Dependence as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.

Interestingly, the risk allele varies between populations. Among African-Americans, the haplotype C-C-G of rs2491397-rs2184026-rs3750344 had a significant positive association with nicotine dependence. Among European-Americans, for rs1435252-rs3780422-rs2779562-rs3750344, the C-A-C-A haplotype was positively associated with nicotine dependence while the T-A-T-A haplotype was negatively associated.[PMID 15759211]

OMIM	607340
Desc	GAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2
Variant
Related	also

OMIM	607340
Desc
Variant	0001
Related	also

OMIM	607340
Desc
Variant	0002
Related	also

OMIM	607340
Desc
Variant	0003
Related	also

[PMID 19763258] Association and interaction analyses of GABBR1 and GABBR2 with nicotine dependence in European- and African-American populations.

ClinVar
Risk	rs3750344(G;G)
Alt	rs3750344(G;G)
Reference	Rs3750344(A;A)
Significance	Other
Disease	Tobacco addiction
Variation	info
Gene	GABBR2
CLNDBN	Tobacco addiction, susceptibility to
Reversed	1
HGVS	NC_000009.11:g.101340316T>C
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000003495.1,