rs4293393

minus

Geno	Mag	Summary
(C;C)		0.76x reduced risk of CKD for C allele
(C;T)
(T;T)	0	1.25x Increased Risk of CKD for T allele in Icelandic study

Reference

GRCh38 38.1/141

Chromosome

16

Position

20353266

Gene

UMOD

is a	snp
is	mentioned by
dbSNP	rs4293393
dbSNP (classic)	rs4293393
ClinGen	rs4293393
ebi	rs4293393
HLI	rs4293393
Exac	rs4293393
Gnomad	rs4293393
Varsome	rs4293393
LitVar	rs4293393
Map	rs4293393
PheGenI	rs4293393
Biobank	rs4293393
1000 genomes	rs4293393
hgdp	rs4293393
ensembl	rs4293393
geneview	rs4293393
scholar	rs4293393
google	rs4293393
pharmgkb	rs4293393
gwascentral	rs4293393
openSNP	rs4293393
23andMe	rs4293393
SNPshot	rs4293393
SNPdbe	rs4293393
MSV3d	rs4293393
GWAS Ctlg	rs4293393

GMAF

0.1685

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

23andMe blog each G at rs4293393 decreased the odds of chronic kidney disease by 24%. Approximately 18% of people with European ancestry have at least one G at this SNP. [1]

DeCode reports that the T allele of rs4293393 is associated with kidney stones and chronic kidney disease. [2] This SNP may also be associated with susceptibility to gout, hypertension, and diabetes. [PMID 20686651 ]

[PMID 19959715 ] Uromodulin Levels Associate with a Common UMOD Variant and Risk for Incident CKD

[PMID 20686651 ] Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones-Role of Age and Comorbid Diseases

[PMID 20222955 ] A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level.