rs1859962
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 2.3 | 1.28x increased risk for prostate cancer |
| (G;T) | 0 | normal risk |
| (T;T) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 71112612 |
| Gene | CASC17 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1859962 |
| dbSNP (classic) | rs1859962 |
| ClinGen | rs1859962 |
| ebi | rs1859962 |
| HLI | rs1859962 |
| Exac | rs1859962 |
| Gnomad | rs1859962 |
| Varsome | rs1859962 |
| LitVar | rs1859962 |
| Map | rs1859962 |
| PheGenI | rs1859962 |
| Biobank | rs1859962 |
| 1000 genomes | rs1859962 |
| hgdp | rs1859962 |
| ensembl | rs1859962 |
| geneview | rs1859962 |
| scholar | rs1859962 |
| rs1859962 | |
| pharmgkb | rs1859962 |
| gwascentral | rs1859962 |
| openSNP | rs1859962 |
| 23andMe | rs1859962 |
| SNPshot | rs1859962 |
| SNPdbe | rs1859962 |
| MSV3d | rs1859962 |
| GWAS Ctlg | rs1859962 |
| GMAF | 0.3976 |
| Max Magnitude | 2.3 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1859962 is a SNP on chromosome 17q24.3, associated with increased risk for prostate cancer in several studies.
In a study of over 3,600 Caucasians with prostate cancer, rs1859962 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs1859962(G;G) risk genotype yields an odds ratio for developing prostate cancer of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk.10.1056/NEJMoa075819
news linked to Prostate cancer and type-2 diabetes
cancer-genetics these snps influence genetic risk for prostate cancer
- the haplotype rs6983267 rs1016343 rs4242384
- rs7501939
- rs1859962
- rs2660753
- rs9364554
- rs6465657
- rs10993994
- rs7931342
- rs2735839
- rs5945619
- rs10993994
| GWAS | |
|---|---|
| SNP | rs1859962 |
| PubMedID | [PMID 17603485] |
| Condition | Prostate cancer |
| Gene | Intergenic |
| Risk Allele | G |
| pValue | 3.00E-010 |
| OR | 1.2 |
| 95% CI | 1.14-1.27 |
| GWAS snp | |
|---|---|
| PMID | [PMID 18264097] |
| Trait | Prostate cancer |
| Title | Multiple newly identified loci associated with prostate cancer susceptibility |
| Risk Allele | G |
| P-val | 9.9999999999999995E-7 |
| Odds Ratio | 1.26 [NR] |
| GWAS snp | |
|---|---|
| PMID | [PMID 19767753 ]
|
| Trait | Prostate cancer |
| Title | Identification of seven new prostate cancer susceptibility loci through a genome-wide association study |
| Risk Allele | T |
| P-val | 2E-16 |
| Odds Ratio | NR NR |
[PMID 21086507] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)
| GWAS snp | |
|---|---|
| PMID | [PMID 21743057]
|
| Trait | |
| Title | Genome-wide association study identifies new prostate cancer susceptibility loci. |
| Risk Allele | G |
| P-val | 3E-11 |
| Odds Ratio | 1.2700 [1.18-1.37] |
[PMID 21959049] Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population
[PMID 22665440] Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus
[PMID 18491292] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
[PMID 18701471] Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.
[PMID 18794092] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
[PMID 18974127] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
[PMID 19058137] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.
[PMID 19104501] Prostate cancer genomics: towards a new understanding.
[PMID 19318432] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
[PMID 19366828] Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.
[PMID 19371897] Pathological outcomes associated with the 17q prostate cancer risk variants.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19549807] Prostate cancer risk associated loci in African Americans.
[PMID 19727433] Cancer genetic association studies in the genome-wide age.
[PMID 20026053] WITHDRAWN: Relationships between 8q24 and 17q risk loci and sporadic or latent prostate cancer and the impacts of these loci on the clinicopathologic characteristics of prostate cancer.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21456070] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).
[PMID 21538423] Early onset prostate cancer has a significant genetic component.
[PMID 21557267] A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population.
[PMID 22077888] Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.
[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
[PMID 24037955] The presence of prostate cancer at biopsy is predicted by a number of genetic variants
